Do human tumor-associated viruses play a role in the development of synovial sarcoma?

BACKGROUND: To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas. FINDINGS: In total 41 synovial sarcoma...

Descripción completa

Detalles Bibliográficos
Autores principales: Lenze, Ulrich, Pohlig, Florian, Mühlhofer, Heinrich, Lenze, Florian, Toepfer, Andreas, Rechl, Hans, Burgkart, Rainer, von Eisenhart-Rothe, Rüdiger, Straub, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412097/
https://www.ncbi.nlm.nih.gov/pubmed/25922658
http://dx.doi.org/10.1186/s13569-015-0027-x
Descripción
Sumario:BACKGROUND: To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas. FINDINGS: In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected. CONCLUSION: An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities.

Ejemplares similares