Do human tumor-associated viruses play a role in the development of synovial sarcoma?

BACKGROUND: To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas. FINDINGS: In total 41 synovial sarcoma...

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Autores principales: Lenze, Ulrich, Pohlig, Florian, Mühlhofer, Heinrich, Lenze, Florian, Toepfer, Andreas, Rechl, Hans, Burgkart, Rainer, von Eisenhart-Rothe, Rüdiger, Straub, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412097/
https://www.ncbi.nlm.nih.gov/pubmed/25922658
http://dx.doi.org/10.1186/s13569-015-0027-x
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author Lenze, Ulrich
Pohlig, Florian
Mühlhofer, Heinrich
Lenze, Florian
Toepfer, Andreas
Rechl, Hans
Burgkart, Rainer
von Eisenhart-Rothe, Rüdiger
Straub, Melanie
author_facet Lenze, Ulrich
Pohlig, Florian
Mühlhofer, Heinrich
Lenze, Florian
Toepfer, Andreas
Rechl, Hans
Burgkart, Rainer
von Eisenhart-Rothe, Rüdiger
Straub, Melanie
author_sort Lenze, Ulrich
collection PubMed
description BACKGROUND: To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas. FINDINGS: In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected. CONCLUSION: An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities.
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spelling pubmed-44120972015-04-29 Do human tumor-associated viruses play a role in the development of synovial sarcoma? Lenze, Ulrich Pohlig, Florian Mühlhofer, Heinrich Lenze, Florian Toepfer, Andreas Rechl, Hans Burgkart, Rainer von Eisenhart-Rothe, Rüdiger Straub, Melanie Clin Sarcoma Res Short Report BACKGROUND: To date, the pathomechanism of soft tissue sarcomas such as synovial sarcoma remains unclear whereas even a viral etiology was suspected. Aim of this study was to analyze whether EBV, HHV-8 or HPV play a role in the development of synovial sarcomas. FINDINGS: In total 41 synovial sarcomas were included in this retrospective study. For detection of EBV 1/2 and HHV-8, resection specimens were analyzed with regard to virus-specific sequences using a SingleStep PCR. HPV analysis was carried out by an HPV-specific multiplex-PCR and subsequent array-hybridization for HPV-typing. No virus-specific DNA of EBV, HHV-8 or HPV was detected. CONCLUSION: An involvement of these viruses in the etiology of synovial sarcoma was not detected but further studies are needed with different virus types and sarcoma entities. BioMed Central 2015-04-15 /pmc/articles/PMC4412097/ /pubmed/25922658 http://dx.doi.org/10.1186/s13569-015-0027-x Text en © Lenze et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Lenze, Ulrich
Pohlig, Florian
Mühlhofer, Heinrich
Lenze, Florian
Toepfer, Andreas
Rechl, Hans
Burgkart, Rainer
von Eisenhart-Rothe, Rüdiger
Straub, Melanie
Do human tumor-associated viruses play a role in the development of synovial sarcoma?
title Do human tumor-associated viruses play a role in the development of synovial sarcoma?
title_full Do human tumor-associated viruses play a role in the development of synovial sarcoma?
title_fullStr Do human tumor-associated viruses play a role in the development of synovial sarcoma?
title_full_unstemmed Do human tumor-associated viruses play a role in the development of synovial sarcoma?
title_short Do human tumor-associated viruses play a role in the development of synovial sarcoma?
title_sort do human tumor-associated viruses play a role in the development of synovial sarcoma?
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412097/
https://www.ncbi.nlm.nih.gov/pubmed/25922658
http://dx.doi.org/10.1186/s13569-015-0027-x
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