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Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas
BACKGROUND: Tumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emission tomography (PET) tracer [(18)F]EF5 and tumor growth. Our second goal was t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412195/ https://www.ncbi.nlm.nih.gov/pubmed/25977879 http://dx.doi.org/10.1186/s13550-014-0065-z |
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author | Silvoniemi, Antti Silén, Jonna Forsback, Sarita Löyttyniemi, Eliisa Schrey, Aleksi R Solin, Olof Grénman, Reidar Minn, Heikki Grönroos, Tove J |
author_facet | Silvoniemi, Antti Silén, Jonna Forsback, Sarita Löyttyniemi, Eliisa Schrey, Aleksi R Solin, Olof Grénman, Reidar Minn, Heikki Grönroos, Tove J |
author_sort | Silvoniemi, Antti |
collection | PubMed |
description | BACKGROUND: Tumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emission tomography (PET) tracer [(18)F]EF5 and tumor growth. Our second goal was to assess the variability in the uptake of [(18)F]EF5 in tumor between two scans. METHODS: Four human head and neck squamous cell carcinoma (UT-SCC) cell lines were xenografted in flank or neck of nude mice, and tumor size was closely monitored over the study period. The tumors were clearly visible when the first [(18)F]EF5 scan was acquired. After an exponential growth phase, the tumors were imaged again with [(18)F]EF5 and also with (18)F-fluorodeoxyglucose ([(18)F]FDG). RESULTS: There was a clear correlation between the percentage of tumor growth rate per day and the [(18)F]EF5 uptake in the latter scan (r = 0.766, p = 0.01). The uptake of [(18)F]EF5 in the first scan and the uptake of [(18)F]FDG did not significantly correlate with the tumor growth rate. We also observed considerable variations in the uptake of [(18)F]EF5 between the two scans. CONCLUSIONS: The uptake of [(18)F]EF5 in the late phase of exponential tumor growth is associated with the tumor growth rate in mice bearing HNC xenografts. |
format | Online Article Text |
id | pubmed-4412195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-44121952015-05-14 Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas Silvoniemi, Antti Silén, Jonna Forsback, Sarita Löyttyniemi, Eliisa Schrey, Aleksi R Solin, Olof Grénman, Reidar Minn, Heikki Grönroos, Tove J EJNMMI Res Original Research BACKGROUND: Tumor hypoxia is linked to invasion and metastasis but whether this associates with tumor growth rate is not well understood. We aimed to study the relationship between hypoxia evaluated with the positron emission tomography (PET) tracer [(18)F]EF5 and tumor growth. Our second goal was to assess the variability in the uptake of [(18)F]EF5 in tumor between two scans. METHODS: Four human head and neck squamous cell carcinoma (UT-SCC) cell lines were xenografted in flank or neck of nude mice, and tumor size was closely monitored over the study period. The tumors were clearly visible when the first [(18)F]EF5 scan was acquired. After an exponential growth phase, the tumors were imaged again with [(18)F]EF5 and also with (18)F-fluorodeoxyglucose ([(18)F]FDG). RESULTS: There was a clear correlation between the percentage of tumor growth rate per day and the [(18)F]EF5 uptake in the latter scan (r = 0.766, p = 0.01). The uptake of [(18)F]EF5 in the first scan and the uptake of [(18)F]FDG did not significantly correlate with the tumor growth rate. We also observed considerable variations in the uptake of [(18)F]EF5 between the two scans. CONCLUSIONS: The uptake of [(18)F]EF5 in the late phase of exponential tumor growth is associated with the tumor growth rate in mice bearing HNC xenografts. Springer 2014-12-16 /pmc/articles/PMC4412195/ /pubmed/25977879 http://dx.doi.org/10.1186/s13550-014-0065-z Text en Copyright © 2014 Silvoniemi et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Original Research Silvoniemi, Antti Silén, Jonna Forsback, Sarita Löyttyniemi, Eliisa Schrey, Aleksi R Solin, Olof Grénman, Reidar Minn, Heikki Grönroos, Tove J Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas |
title | Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas |
title_full | Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas |
title_fullStr | Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas |
title_full_unstemmed | Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas |
title_short | Evaluation of repeated [(18)F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas |
title_sort | evaluation of repeated [(18)f]ef5 pet/ct scans and tumor growth rate in experimental head and neck carcinomas |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412195/ https://www.ncbi.nlm.nih.gov/pubmed/25977879 http://dx.doi.org/10.1186/s13550-014-0065-z |
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