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The relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment

BACKGROUND: Hyperglycemia appears to play a significant role on the inflammatory cytokines production. Beta2-microglobulin (beta2M) is accumulated in the circulation of dialysis patients. We studied the relationship between glycemic control defined by glucose serum concentrations and insulin resista...

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Autores principales: Raikou, Vaia D, Kyriaki, Despina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412206/
https://www.ncbi.nlm.nih.gov/pubmed/25922828
http://dx.doi.org/10.1186/s40200-015-0162-1
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author Raikou, Vaia D
Kyriaki, Despina
author_facet Raikou, Vaia D
Kyriaki, Despina
author_sort Raikou, Vaia D
collection PubMed
description BACKGROUND: Hyperglycemia appears to play a significant role on the inflammatory cytokines production. Beta2-microglobulin (beta2M) is accumulated in the circulation of dialysis patients. We studied the relationship between glycemic control defined by glucose serum concentrations and insulin resistance, beta2M and markers of inflammation in patients on renal replacement therapies with or/and without diabetes mellitus. METHODS: We enrolled 96 dialyzed patients, 62 males and 34 females. The treatment modalities which were applied were : regular hemodialysis (HD, n = 34), predilution hemodiafiltration (HDF, n = 42) and peritoneal dialysis (PD, n = 20). Dialysis adequacy was defined by Kt/V for urea.Beta2M and insulin serum concentrations were measured by radioimmunoassays. hsCRP and TNF-α serum concentrations were measured by ELISA. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR).We examined the association of elevated serum glucose with inflammatory factors and we built a multivariable model to investigate if glucose could be a potential determinant of beta2M serum levels. RESULTS: Serum glucose was positively correlated with beta2M and TNF-α (r = 0.320, p = 0.002 and r = 0.215, p = 0.03 respectively).We observed significant association between the patients with higher serum glucose concentrations and the patients with greater beta2Μ concentrations (x(2) = 4.44, p = 0.03). Multivariable model showed that glucose acts as a significant independent determinant of beta2M adjusting for age, gender, dialysis modality and metabolic acidosis status. CONCLUSIONS: The elevated glucose concentrations were positively associated with both, greater beta2M serum concentrations and up-regulated inflammatory procedure in dialysis patients with or/and without diabetes mellitus.
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spelling pubmed-44122062015-04-29 The relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment Raikou, Vaia D Kyriaki, Despina J Diabetes Metab Disord Research Article BACKGROUND: Hyperglycemia appears to play a significant role on the inflammatory cytokines production. Beta2-microglobulin (beta2M) is accumulated in the circulation of dialysis patients. We studied the relationship between glycemic control defined by glucose serum concentrations and insulin resistance, beta2M and markers of inflammation in patients on renal replacement therapies with or/and without diabetes mellitus. METHODS: We enrolled 96 dialyzed patients, 62 males and 34 females. The treatment modalities which were applied were : regular hemodialysis (HD, n = 34), predilution hemodiafiltration (HDF, n = 42) and peritoneal dialysis (PD, n = 20). Dialysis adequacy was defined by Kt/V for urea.Beta2M and insulin serum concentrations were measured by radioimmunoassays. hsCRP and TNF-α serum concentrations were measured by ELISA. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR).We examined the association of elevated serum glucose with inflammatory factors and we built a multivariable model to investigate if glucose could be a potential determinant of beta2M serum levels. RESULTS: Serum glucose was positively correlated with beta2M and TNF-α (r = 0.320, p = 0.002 and r = 0.215, p = 0.03 respectively).We observed significant association between the patients with higher serum glucose concentrations and the patients with greater beta2Μ concentrations (x(2) = 4.44, p = 0.03). Multivariable model showed that glucose acts as a significant independent determinant of beta2M adjusting for age, gender, dialysis modality and metabolic acidosis status. CONCLUSIONS: The elevated glucose concentrations were positively associated with both, greater beta2M serum concentrations and up-regulated inflammatory procedure in dialysis patients with or/and without diabetes mellitus. BioMed Central 2015-04-23 /pmc/articles/PMC4412206/ /pubmed/25922828 http://dx.doi.org/10.1186/s40200-015-0162-1 Text en © Raikou and Kyriaki; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Raikou, Vaia D
Kyriaki, Despina
The relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment
title The relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment
title_full The relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment
title_fullStr The relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment
title_full_unstemmed The relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment
title_short The relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment
title_sort relationship between glycemic control, beta2-microglobulin and inflammation in patients on maintenance dialysis treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412206/
https://www.ncbi.nlm.nih.gov/pubmed/25922828
http://dx.doi.org/10.1186/s40200-015-0162-1
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