Cargando…

Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found?

Pathologic staging of oncologic specimens includes the identification of the accurate lymph node status. Retrieving more lymph nodes leads to a more reliable N0 status in the TNM classification. The aim of this prospective study was to evaluate whether more lymph nodes can be retrieved from oncologi...

Descripción completa

Detalles Bibliográficos
Autores principales: de Burlet, Kirsten J., van den Hout, Mari F. C. M., Putter, Hein, Smit, Vincent T. H. B. M., Hartgrink, Henk H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412279/
https://www.ncbi.nlm.nih.gov/pubmed/25691110
http://dx.doi.org/10.1007/s11605-015-2764-9
_version_ 1782368636107751424
author de Burlet, Kirsten J.
van den Hout, Mari F. C. M.
Putter, Hein
Smit, Vincent T. H. B. M.
Hartgrink, Henk H.
author_facet de Burlet, Kirsten J.
van den Hout, Mari F. C. M.
Putter, Hein
Smit, Vincent T. H. B. M.
Hartgrink, Henk H.
author_sort de Burlet, Kirsten J.
collection PubMed
description Pathologic staging of oncologic specimens includes the identification of the accurate lymph node status. Retrieving more lymph nodes leads to a more reliable N0 status in the TNM classification. The aim of this prospective study was to evaluate whether more lymph nodes can be retrieved from oncologic resection specimens when more time is invested in the search and if this contributes to a more reliable N-status in the individual patient. A total of 67 gastrointestinal oncologic specimens were reexamined for additional lymph nodes. The mean number of lymph nodes collected in the prospective group was compared against two retrospective groups, one before minima for lymph node counts were set (retrospective group 1) and one after (retrospective group 2). More lymph nodes were dissected per specimen in the prospective group (24.1 lymph nodes), compared to the retrospective group (14.3 lymph nodes, P = <0.001). During the study period, more patients were diagnosed as pN+ compared to the two retrospective groups (62.7 vs. 47.8 % respectively, P = 0.082). Significantly more lymph nodes can be found in oncologic specimens when more time is invested in the search. This will result in more accurate staging of the tumor.
format Online
Article
Text
id pubmed-4412279
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-44122792015-05-06 Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found? de Burlet, Kirsten J. van den Hout, Mari F. C. M. Putter, Hein Smit, Vincent T. H. B. M. Hartgrink, Henk H. J Gastrointest Surg Original Article Pathologic staging of oncologic specimens includes the identification of the accurate lymph node status. Retrieving more lymph nodes leads to a more reliable N0 status in the TNM classification. The aim of this prospective study was to evaluate whether more lymph nodes can be retrieved from oncologic resection specimens when more time is invested in the search and if this contributes to a more reliable N-status in the individual patient. A total of 67 gastrointestinal oncologic specimens were reexamined for additional lymph nodes. The mean number of lymph nodes collected in the prospective group was compared against two retrospective groups, one before minima for lymph node counts were set (retrospective group 1) and one after (retrospective group 2). More lymph nodes were dissected per specimen in the prospective group (24.1 lymph nodes), compared to the retrospective group (14.3 lymph nodes, P = <0.001). During the study period, more patients were diagnosed as pN+ compared to the two retrospective groups (62.7 vs. 47.8 % respectively, P = 0.082). Significantly more lymph nodes can be found in oncologic specimens when more time is invested in the search. This will result in more accurate staging of the tumor. Springer US 2015-02-18 2015 /pmc/articles/PMC4412279/ /pubmed/25691110 http://dx.doi.org/10.1007/s11605-015-2764-9 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
de Burlet, Kirsten J.
van den Hout, Mari F. C. M.
Putter, Hein
Smit, Vincent T. H. B. M.
Hartgrink, Henk H.
Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found?
title Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found?
title_full Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found?
title_fullStr Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found?
title_full_unstemmed Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found?
title_short Total Number of Lymph Nodes in Oncologic Resections, Is There More to Be Found?
title_sort total number of lymph nodes in oncologic resections, is there more to be found?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412279/
https://www.ncbi.nlm.nih.gov/pubmed/25691110
http://dx.doi.org/10.1007/s11605-015-2764-9
work_keys_str_mv AT deburletkirstenj totalnumberoflymphnodesinoncologicresectionsistheremoretobefound
AT vandenhoutmarifcm totalnumberoflymphnodesinoncologicresectionsistheremoretobefound
AT putterhein totalnumberoflymphnodesinoncologicresectionsistheremoretobefound
AT smitvincentthbm totalnumberoflymphnodesinoncologicresectionsistheremoretobefound
AT hartgrinkhenkh totalnumberoflymphnodesinoncologicresectionsistheremoretobefound