Animal models of multiple system atrophy

Since their introduction in 1996, animal models of multiple system atrophy (MSA) have generated important insights into pathogenesis and interventional therapies. Toxin and genetic approaches have been used alone or in combination to replicate progressive motor and non-motor symptoms reflecting huma...

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Detalles Bibliográficos
Autores principales: Stefanova, Nadia, Wenning, Gregor K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412689/
https://www.ncbi.nlm.nih.gov/pubmed/25585910
http://dx.doi.org/10.1007/s10286-014-0266-6
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author Stefanova, Nadia
Wenning, Gregor K.
author_facet Stefanova, Nadia
Wenning, Gregor K.
author_sort Stefanova, Nadia
collection PubMed
description Since their introduction in 1996, animal models of multiple system atrophy (MSA) have generated important insights into pathogenesis and interventional therapies. Toxin and genetic approaches have been used alone or in combination to replicate progressive motor and non-motor symptoms reflecting human neuropathology. Here, we review these developments and discuss the advantages and limitations of the MSA animal models, as well as their application in preclinical target validation.
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spelling pubmed-44126892015-05-06 Animal models of multiple system atrophy Stefanova, Nadia Wenning, Gregor K. Clin Auton Res Review Article Since their introduction in 1996, animal models of multiple system atrophy (MSA) have generated important insights into pathogenesis and interventional therapies. Toxin and genetic approaches have been used alone or in combination to replicate progressive motor and non-motor symptoms reflecting human neuropathology. Here, we review these developments and discuss the advantages and limitations of the MSA animal models, as well as their application in preclinical target validation. Springer Berlin Heidelberg 2015-01-14 2015 /pmc/articles/PMC4412689/ /pubmed/25585910 http://dx.doi.org/10.1007/s10286-014-0266-6 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review Article
Stefanova, Nadia
Wenning, Gregor K.
Animal models of multiple system atrophy
title Animal models of multiple system atrophy
title_full Animal models of multiple system atrophy
title_fullStr Animal models of multiple system atrophy
title_full_unstemmed Animal models of multiple system atrophy
title_short Animal models of multiple system atrophy
title_sort animal models of multiple system atrophy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412689/
https://www.ncbi.nlm.nih.gov/pubmed/25585910
http://dx.doi.org/10.1007/s10286-014-0266-6
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