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The current state of xenotransplantation
Pigs as a source of grafts for xenotransplantation can help to overcome the rapidly growing shortage of human donors. However, in the case of pig-to-human transplantation, the antibody-xenoantigen complexes lead to the complement activation and immediate hyperacute rejection. Methods eliminating hyp...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412840/ https://www.ncbi.nlm.nih.gov/pubmed/25487710 http://dx.doi.org/10.1007/s13353-014-0261-6 |
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author | Zeyland, J. Lipiński, D. Słomski, R. |
author_facet | Zeyland, J. Lipiński, D. Słomski, R. |
author_sort | Zeyland, J. |
collection | PubMed |
description | Pigs as a source of grafts for xenotransplantation can help to overcome the rapidly growing shortage of human donors. However, in the case of pig-to-human transplantation, the antibody-xenoantigen complexes lead to the complement activation and immediate hyperacute rejection. Methods eliminating hyperacute rejection (HAR) include α1,3-galactosyltransferase (GGTA1) inactivation, regulation of the complement system and modification of the oligosaccharide structure of surface proteins. The humoral immune response control and reduction of the risk of coagulation disorders are the priority tasks in attempts to overcome acute humoral xenograft rejection that may occur after the elimination of HAR. The primary targets for research are connected with the identification of obstacles and development of strategies to tackle them. Because of the magnitude of factors involved in the immune, genetic engineers face a serious problem of producing multitransgenic animals in the shortest possible time. |
format | Online Article Text |
id | pubmed-4412840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-44128402015-05-06 The current state of xenotransplantation Zeyland, J. Lipiński, D. Słomski, R. J Appl Genet Animal Genetics • Review Pigs as a source of grafts for xenotransplantation can help to overcome the rapidly growing shortage of human donors. However, in the case of pig-to-human transplantation, the antibody-xenoantigen complexes lead to the complement activation and immediate hyperacute rejection. Methods eliminating hyperacute rejection (HAR) include α1,3-galactosyltransferase (GGTA1) inactivation, regulation of the complement system and modification of the oligosaccharide structure of surface proteins. The humoral immune response control and reduction of the risk of coagulation disorders are the priority tasks in attempts to overcome acute humoral xenograft rejection that may occur after the elimination of HAR. The primary targets for research are connected with the identification of obstacles and development of strategies to tackle them. Because of the magnitude of factors involved in the immune, genetic engineers face a serious problem of producing multitransgenic animals in the shortest possible time. Springer Berlin Heidelberg 2014-12-07 2015 /pmc/articles/PMC4412840/ /pubmed/25487710 http://dx.doi.org/10.1007/s13353-014-0261-6 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Animal Genetics • Review Zeyland, J. Lipiński, D. Słomski, R. The current state of xenotransplantation |
title | The current state of xenotransplantation |
title_full | The current state of xenotransplantation |
title_fullStr | The current state of xenotransplantation |
title_full_unstemmed | The current state of xenotransplantation |
title_short | The current state of xenotransplantation |
title_sort | current state of xenotransplantation |
topic | Animal Genetics • Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412840/ https://www.ncbi.nlm.nih.gov/pubmed/25487710 http://dx.doi.org/10.1007/s13353-014-0261-6 |
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