Design and Synthesis of Novel Arylketo-containing P1-P3 Linked Macro-cyclic BACE-1 Inhibitors

A series of arylketo-containing P1-P3 linked macrocyclic BACE-1 inhibitors were designed, synthesized, and compared with compounds with a previously known and extensively studied corresponding P2 isophthalamide moiety with the aim to improve on permeability whilst retaining the enzyme- and cell-base...

Descripción completa

Detalles Bibliográficos
Autores principales: Sandgren, Veronica, Belda, Oscar, Kvarnström, Ingemar, Lindberg, Jimmy, Samuelsson, Bertil, Dahlgren, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412958/
https://www.ncbi.nlm.nih.gov/pubmed/25937848
http://dx.doi.org/10.2174/1874104501509010013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4412958/
https://www.ncbi.nlm.nih.gov/pubmed/25937848
http://dx.doi.org/10.2174/1874104501509010013

Ejemplares similares