Fatty acid carbon is essential for dNTP synthesis in endothelial cells

The metabolism of endothelial cells (ECs) during vessel sprouting remains poorly studied. Here, we report that endothelial loss of CPT1a, a rate-limiting enzyme of fatty acid oxidation (FAO), caused vascular sprouting defects due to impaired proliferation, not migration of ECs. Reduction of FAO in E...

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Detalles Bibliográficos
Autores principales: Schoors, Sandra, Bruning, Ulrike, Missiaen, Rindert, Queiroz, Karla CS, Borgers, Gitte, Elia, Ilaria, Zecchin, Annalisa, Cantelmo, Anna Rita, Christen, Stefan, Goveia, Jermaine, Heggermont, Ward, Goddé, Lucica, Vinckier, Stefan, Van Veldhoven, Paul P., Eelen, Guy, Schoonjans, Luc, Gerhardt, Holger, Dewerchin, Mieke, Baes, Myriam, De Bock, Katrien, Ghesquière, Bart, Lunt, Sophia Y., Fendt, Sarah-Maria, Carmeliet, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413024/
https://www.ncbi.nlm.nih.gov/pubmed/25830893
http://dx.doi.org/10.1038/nature14362

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