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Inhibition of N-Type Calcium Channels by Fluorophenoxyanilide Derivatives

A set of fluorophenoxyanilides, designed to be simplified analogues of previously reported ω-conotoxin GVIA mimetics, were prepared and tested for N-type calcium channel inhibition in a SH-SY5Y neuroblastoma FLIPR assay. N-type or Ca(v)2.2 channel is a validated target for the treatment of refractor...

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Detalles Bibliográficos
Autores principales:	Gleeson, Ellen C., Graham, Janease E., Spiller, Sandro, Vetter, Irina, Lewis, Richard J., Duggan, Peter J., Tuck, Kellie L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413198/ https://www.ncbi.nlm.nih.gov/pubmed/25871286 http://dx.doi.org/10.3390/md13042030

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