Synthesis and Bioactivity of Luffarin I

The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumo...

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Detalles Bibliográficos
Autores principales: Urosa, Aitor, Marcos, Isidro S., Díez, David, Lithgow, Anna, Plata, Gabriela B., Padrón, José M., Basabe, Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413218/
https://www.ncbi.nlm.nih.gov/pubmed/25903281
http://dx.doi.org/10.3390/md13042407
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author Urosa, Aitor
Marcos, Isidro S.
Díez, David
Lithgow, Anna
Plata, Gabriela B.
Padrón, José M.
Basabe, Pilar
author_facet Urosa, Aitor
Marcos, Isidro S.
Díez, David
Lithgow, Anna
Plata, Gabriela B.
Padrón, José M.
Basabe, Pilar
author_sort Urosa, Aitor
collection PubMed
description The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI(50)) in the range 12–17 μM.
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spelling pubmed-44132182015-05-07 Synthesis and Bioactivity of Luffarin I Urosa, Aitor Marcos, Isidro S. Díez, David Lithgow, Anna Plata, Gabriela B. Padrón, José M. Basabe, Pilar Mar Drugs Article The first synthesis of Luffarin I, sesterterpenolide isolated from sponge Luffariella geometrica, has been accomplished from commercially available sclareol. The key strategy involved in this synthesis is the diastereoselective reduction of an intermediate ketone. Luffarin I against human solid tumor cell lines showed antiproliferative activities (GI(50)) in the range 12–17 μM. MDPI 2015-04-20 /pmc/articles/PMC4413218/ /pubmed/25903281 http://dx.doi.org/10.3390/md13042407 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Urosa, Aitor
Marcos, Isidro S.
Díez, David
Lithgow, Anna
Plata, Gabriela B.
Padrón, José M.
Basabe, Pilar
Synthesis and Bioactivity of Luffarin I
title Synthesis and Bioactivity of Luffarin I
title_full Synthesis and Bioactivity of Luffarin I
title_fullStr Synthesis and Bioactivity of Luffarin I
title_full_unstemmed Synthesis and Bioactivity of Luffarin I
title_short Synthesis and Bioactivity of Luffarin I
title_sort synthesis and bioactivity of luffarin i
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413218/
https://www.ncbi.nlm.nih.gov/pubmed/25903281
http://dx.doi.org/10.3390/md13042407
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