Cargando…

Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model

Free radicals are one of the frequent products of normal cellular metabolism. Disparity of metabolism and excessive generation of free radicals predisposes to disorders like Parkinson's disease, Alzheimer's disease, and aging phenomenon. Curculigo orchioides Gaertn. is known for “adaptogen...

Descripción completa

Detalles Bibliográficos
Autores principales: Ramchandani, Dipica, Ganeshpurkar, Aditya, Bansal, Divya, Karchuli, Manvendra Singh, Dubey, Nazneen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413403/
https://www.ncbi.nlm.nih.gov/pubmed/25948959
http://dx.doi.org/10.4103/0971-6580.155323
_version_ 1782368775652245504
author Ramchandani, Dipica
Ganeshpurkar, Aditya
Bansal, Divya
Karchuli, Manvendra Singh
Dubey, Nazneen
author_facet Ramchandani, Dipica
Ganeshpurkar, Aditya
Bansal, Divya
Karchuli, Manvendra Singh
Dubey, Nazneen
author_sort Ramchandani, Dipica
collection PubMed
description Free radicals are one of the frequent products of normal cellular metabolism. Disparity of metabolism and excessive generation of free radicals predisposes to disorders like Parkinson's disease, Alzheimer's disease, and aging phenomenon. Curculigo orchioides Gaertn. is known for “adaptogen” and “aphrodisiac” activity and has been proved for antiasthmatic, estrogenic, antiosteoporotic activity along with protection from cisplatin-induced cell damage. C. orchioides was powdered and subjected to soxhlet extraction using methanol. Phytochemical studies and estimation of polyphenols and flavonoids was performed. Acute toxicity studies were performed by Organization for Economic Cooperation and Development OECD guidelines. Animals were treated with cyclophosphamide to induce neurotoxicity. Curculigo orchioides was powdered and subjected to soxhlet extraction using methanol. Catalase, superoxide dismutase, glutathione peroxidase, and lipid peroxidation were estimated by reported methods. C. orchioides (400 mg/kg) significantly promoted restoration of catalase (P < 0.005), superoxide dismutase (P < 0.005), and glutathion (P < 0.05) levels. Similarly, a very significant decrease (P < 0.005) in the levels of malondialdehyde was observed. In all cases as mentioned previously, C. orchioides at dose 200 mg/kg promoted significant (P < 0.05) restoration of enzyme levels. C. orchioides (Kali Musli) is rich source of phytochemicals like flavonoids and polyphenols. Flavonoids and polyphenols are reputed to demonstrate neuroprotective effect. These phytochemicals in the present study might be responsible to demonstrate neuroprotective effect.
format Online
Article
Text
id pubmed-4413403
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-44134032015-05-06 Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model Ramchandani, Dipica Ganeshpurkar, Aditya Bansal, Divya Karchuli, Manvendra Singh Dubey, Nazneen Toxicol Int Original Article Free radicals are one of the frequent products of normal cellular metabolism. Disparity of metabolism and excessive generation of free radicals predisposes to disorders like Parkinson's disease, Alzheimer's disease, and aging phenomenon. Curculigo orchioides Gaertn. is known for “adaptogen” and “aphrodisiac” activity and has been proved for antiasthmatic, estrogenic, antiosteoporotic activity along with protection from cisplatin-induced cell damage. C. orchioides was powdered and subjected to soxhlet extraction using methanol. Phytochemical studies and estimation of polyphenols and flavonoids was performed. Acute toxicity studies were performed by Organization for Economic Cooperation and Development OECD guidelines. Animals were treated with cyclophosphamide to induce neurotoxicity. Curculigo orchioides was powdered and subjected to soxhlet extraction using methanol. Catalase, superoxide dismutase, glutathione peroxidase, and lipid peroxidation were estimated by reported methods. C. orchioides (400 mg/kg) significantly promoted restoration of catalase (P < 0.005), superoxide dismutase (P < 0.005), and glutathion (P < 0.05) levels. Similarly, a very significant decrease (P < 0.005) in the levels of malondialdehyde was observed. In all cases as mentioned previously, C. orchioides at dose 200 mg/kg promoted significant (P < 0.05) restoration of enzyme levels. C. orchioides (Kali Musli) is rich source of phytochemicals like flavonoids and polyphenols. Flavonoids and polyphenols are reputed to demonstrate neuroprotective effect. These phytochemicals in the present study might be responsible to demonstrate neuroprotective effect. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4413403/ /pubmed/25948959 http://dx.doi.org/10.4103/0971-6580.155323 Text en Copyright: © Toxicology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ramchandani, Dipica
Ganeshpurkar, Aditya
Bansal, Divya
Karchuli, Manvendra Singh
Dubey, Nazneen
Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model
title Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model
title_full Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model
title_fullStr Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model
title_full_unstemmed Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model
title_short Protective Effect of Curculigo Orchioides Extract on Cyclophosphamide-Induced Neurotoxicity in Murine Model
title_sort protective effect of curculigo orchioides extract on cyclophosphamide-induced neurotoxicity in murine model
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413403/
https://www.ncbi.nlm.nih.gov/pubmed/25948959
http://dx.doi.org/10.4103/0971-6580.155323
work_keys_str_mv AT ramchandanidipica protectiveeffectofcurculigoorchioidesextractoncyclophosphamideinducedneurotoxicityinmurinemodel
AT ganeshpurkaraditya protectiveeffectofcurculigoorchioidesextractoncyclophosphamideinducedneurotoxicityinmurinemodel
AT bansaldivya protectiveeffectofcurculigoorchioidesextractoncyclophosphamideinducedneurotoxicityinmurinemodel
AT karchulimanvendrasingh protectiveeffectofcurculigoorchioidesextractoncyclophosphamideinducedneurotoxicityinmurinemodel
AT dubeynazneen protectiveeffectofcurculigoorchioidesextractoncyclophosphamideinducedneurotoxicityinmurinemodel