Direct conversion of human myoblasts into brown-like adipocytes by engineered superactive PPARγ

OBJECTIVE: To determine whether super-activation of PPARγ can reprogram human myoblasts into brownlike adipocytes and to establish a new cell model for browning research. METHODS: To enhance the PPARγ signaling, we fused M3, the transactivation domain of MyoD, to PPARγ. PPARγ and M3-PPARγ-lentiviral...

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Detalles Bibliográficos
Autores principales: Zhu, Yanbei, Yang, Rongze, McLenithan, John, Yu, Daozhan, Wang, Hong, Wang, Yaping, Singh, Devinder, Olson, John, Sztalryd, Carole, Zhu, Dalong, Gong, Da-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413469/
https://www.ncbi.nlm.nih.gov/pubmed/25919922
http://dx.doi.org/10.1002/oby.21062

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