Measurement of H(2)O(2) within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

Hydrogen peroxide (H(2)O(2)) is central to mitochondrial oxidative damage and redox signaling, but its roles are poorly understood due to the difficulty of measuring mitochondrial H(2)O(2) in vivo. Here we report a ratiometric mass spectrometry probe approach to assess mitochondrial matrix H(2)O(2)...

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Detalles Bibliográficos
Autores principales: Cochemé, Helena M., Quin, Caroline, McQuaker, Stephen J., Cabreiro, Filipe, Logan, Angela, Prime, Tracy A., Abakumova, Irina, Patel, Jigna V., Fearnley, Ian M., James, Andrew M., Porteous, Carolyn M., Smith, Robin A.J., Saeed, Saima, Carré, Jane E., Singer, Mervyn, Gems, David, Hartley, Richard C., Partridge, Linda, Murphy, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413513/
https://www.ncbi.nlm.nih.gov/pubmed/21356523
http://dx.doi.org/10.1016/j.cmet.2011.02.003

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