Cargando…

Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia

Flavopiridol is a small molecule inhibitor of cyclin-dependent kinases (CDK) known to impair global transcription via inactivation of positive transcription elongation factor b. It has been demonstrated to have significant activity predominantly in chronic lymphocytic leukemia and acute myeloid leuk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yeh, Yuh-Ying, Chen, Rong, Hessler, Joshua, Mahoney, Emilia, Lehman, Amy M., Heerema, Nyla A., Grever, Michael R., Plunkett, William, Byrd, John C., Johnson, Amy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413609/ https://www.ncbi.nlm.nih.gov/pubmed/25596730

Ejemplares similares

Dinaciclib is a Novel Cyclin Dependent Kinase Inhibitor with Significant Clinical Activity in Relapsed and Refractory Chronic Lymphocytic Leukemia
por: Flynn, Joseph, et al.
Publicado: (2015)

Risk Factors for Tumor Lysis Syndrome in patients with Chronic Lymphocytic Leukemia Treated with the Cyclin Dependent Kinase Inhibitor, Flavopiridol
por: Blum, Kristie A., et al.
Publicado: (2011)

Transcriptional Silencing of MCL-1 Through Cyclin-Dependent Kinase Inhibition in Acute Myeloid Leukemia
por: Tibes, Raoul, et al.
Publicado: (2019)

The awakening of the CDK10/Cyclin M protein kinase
por: Guen, Vincent J., et al.
Publicado: (2017)

The Cyclin-dependent Kinase Cdk2 Regulates Thymocyte Apoptosis
por: Hakem, Anne, et al.
Publicado: (1999)

Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
por: Tavakolian, Shaian, et al.
Publicado: (2020)

Cyclin-Dependent Kinases (CDK) and Their Role in Diseases Development–Review
por: Łukasik, Paweł, et al.
Publicado: (2021)

Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock
por: Brenna, Andrea, et al.
Publicado: (2019)

Prognostic significance of translocations in the presence of mutated IGHV and of cytogenetic complexity at diagnosis of chronic lymphocytic leukemia
por: Heerema, Nyla A., et al.
Publicado: (2020)

Impact of Targeted Therapy on Outcome of Chronic Lymphocytic Leukemia Patients with Relapsed Del(17p13.1) Karyotype at a Single Center
por: Stephens, Deborah M., et al.
Publicado: (2014)

Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell division
por: Cedeno-Rosario, Luis, et al.
Publicado: (2022)

Comparison of deregulated expression of cyclin D1 and cyclin E with that of cyclin-dependent kinase 4 (CDK4) and CDK2 in human oesophageal squamous cell carcinoma
por: Matsumoto, M, et al.
Publicado: (1999)

Perspective of Cyclin-dependent kinase 9 (CDK9) as a Drug Target
por: Kryštof, Vladimír, et al.
Publicado: (2012)

Effects of the Cyclin-Dependent Kinase 10 (CDK10) on the Tamoxifen Sensitivity of Keloid Samples
por: Liu, Ying, et al.
Publicado: (2012)

An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1)
por: Liu, Xuanyou, et al.
Publicado: (2022)

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC)
por: Feng, Daorong, et al.
Publicado: (2015)

Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics
por: Choudhary, Gaurav S., et al.
Publicado: (2015)

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines
por: Coxon, Christopher R., et al.
Publicado: (2016)

Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors
por: Sofi, Shazia, et al.
Publicado: (2022)

Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells
por: Marko, D, et al.
Publicado: (2001)

Targeting the cyclin-dependent kinases (CDK) 4/6 in estrogen receptor-positive breast cancers
por: Finn, Richard S., et al.
Publicado: (2016)

The emerging roles and therapeutic potential of cyclin-dependent kinase 11 (CDK11) in human cancer
por: Zhou, Yubing, et al.
Publicado: (2016)

The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1
por: Beaujois, Rémy, et al.
Publicado: (2017)

Genome-wide identification of cyclin-dependent kinase (CDK) genes affecting adipocyte differentiation in cattle
por: Pan, Cuili, et al.
Publicado: (2021)

Cyclin-dependent kinase 7 (CDK7) is an emerging prognostic biomarker and therapeutic target in osteosarcoma
por: Ma, Hangzhan, et al.
Publicado: (2021)

Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors: existing and emerging differences
por: Johnston, Stephen, et al.
Publicado: (2023)

Cyclin-dependent kinases
por: Malumbres, Marcos
Publicado: (2014)

Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency
por: Schütz, Martin, et al.
Publicado: (2023)

A Requirement for Cyclin D3–Cyclin-dependent Kinase (cdk)-4 Assembly in the Cyclic Adenosine Monophosphate–dependent Proliferation of Thyrocytes
por: Depoortere, Fabienne, et al.
Publicado: (1998)

Identification and Functional Characterisation of CRK12:CYC9, a Novel Cyclin-Dependent Kinase (CDK)-Cyclin Complex in Trypanosoma brucei
por: Monnerat, Séverine, et al.
Publicado: (2013)

Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation
por: Liu, Chengcheng, et al.
Publicado: (2017)

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
por: Kang, Jian, et al.
Publicado: (2014)

Extra-cell cycle regulatory functions of cyclin-dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders
por: Kawauchi, Takeshi, et al.
Publicado: (2013)

Greatwall kinase and cyclin B-Cdk1 are both critical constituents of M-phase-promoting factor
por: Hara, Masatoshi, et al.
Publicado: (2012)

Regulation of the G1/S Transition in Hepatocytes: Involvement of the Cyclin-Dependent Kinase Cdk1 in the DNA Replication
por: Corlu, Anne, et al.
Publicado: (2012)

Regulation of Neuronal Ca(v)3.1 Channels by Cyclin-Dependent Kinase 5 (Cdk5)
por: Calderón-Rivera, Aida, et al.
Publicado: (2015)

Correction to: The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1
por: Beaujois, Rémy, et al.
Publicado: (2018)

Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma
por: Ma, Hangzhan, et al.
Publicado: (2018)

Review of rationale and progress toward targeting cyclin-dependent kinase 2 (CDK2) for male contraception(†)
por: Faber, Erik B, et al.
Publicado: (2020)

Cyclin-dependent kinase 9 (CDK9) predicts recurrence in Middle Eastern epithelial ovarian cancer
por: Parvathareddy, Sandeep Kumar, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_66octqjvqumasofs5md9n9kilb