Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth

In addition to genetic alterations, cancer cells are characterized by myriad epigenetic changes. EZH2 is a histone methyltransferase that is over-expressed and mutated in cancer. The EZH2 gain-of-function (GOF) mutations first identified in lymphomas have recently been reported in melanoma (~2%) but...

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Detalles Bibliográficos
Autores principales: Barsotti, Anthony M., Ryskin, Michael, Zhong, Wenyan, Zhang, Wei-Guo, Giannakou, Andreas, Loreth, Christine, Diesl, Veronica, Follettie, Maximillian, Golas, Jonathan, Lee, Michelle, Nichols, Timothy, Fan, Conglin, Li, Gang, Dann, Stephen, Fantin, Valeria R., Arndt, Kim, Verhelle, Dominique, Rollins, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413628/
https://www.ncbi.nlm.nih.gov/pubmed/25671303

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