Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target

Atypical teratoid rhabdoid tumor (AT/RT) is among the most fatal of all pediatric brain tumors. Aside from loss of function mutations in the SMARCB1 (BAF47/INI1/SNF5) chromatin remodeling gene, little is known of other molecular drivers of AT/RT. LIN28A and LIN28B are stem cell factors that regulate...

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Detalles Bibliográficos
Autores principales: Weingart, Melanie F., Roth, Jacquelyn J., Hutt-Cabezas, Marianne, Busse, Tracy M., Kaur, Harpreet, Price, Antoinette, Maynard, Rachael, Rubens, Jeffrey, Taylor, Isabella, Mao, Xing-gang, Xu, Jingying, Kuwahara, Yasumichi, Allen, Sariah J., Erdreich-Epstein, Anat, Weissman, Bernard E., Orr, Brent A., Eberhart, Charles G., Biegel, Jaclyn A., Raabe, Eric H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413645/
https://www.ncbi.nlm.nih.gov/pubmed/25638158

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