Cargando…

Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis

Dietary consumption of genistein, found in soy, has been associated with a potentially protective role in colorectal cancer (CRC) development and progression. Herein we demonstrate that genistein will inhibit human CRC cell invasion and migration, that it does so at non-cytotoxic concentrations and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiao, Xiao, Liu, Zhiguo, Wang, Rui, Wang, Jiayin, Zhang, Song, Cai, Xiqiang, Wu, Kaichun, Bergan, Raymond C., Xu, Li, Fan, Daiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413649/ https://www.ncbi.nlm.nih.gov/pubmed/25605009

Ejemplares similares

Inhibition of cancer cell invasion and metastasis by genistein
por: Pavese, Janet M., et al.
Publicado: (2010)

Loss of vinculin and membrane-bound β-catenin promotes metastasis and predicts poor prognosis in colorectal cancer
por: Li, Ting, et al.
Publicado: (2014)

MicroRNA-149 Inhibits Proliferation and Cell Cycle Progression through the Targeting of ZBTB2 in Human Gastric Cancer
por: Wang, Ying, et al.
Publicado: (2012)

SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis
por: Du, Feng, et al.
Publicado: (2019)

miR-302a Inhibits Metastasis and Cetuximab Resistance in Colorectal Cancer by Targeting NFIB and CD44
por: Sun, Lina, et al.
Publicado: (2019)

FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC
por: Chen, Xilang, et al.
Publicado: (2023)

miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis
por: Li, Xiaowei, et al.
Publicado: (2018)

TAS‐115 inhibits PDGFRα/AXL/FLT‐3 signaling and suppresses lung metastasis of osteosarcoma
por: Yasuda, Naohiro, et al.
Publicado: (2020)

Genistein inhibits human papillary thyroid cancer cell detachment, invasion and metastasis
por: Zhang, Chunyan, et al.
Publicado: (2019)

Genistein suppresses the mitochondrial apoptotic pathway in hippocampal neurons in rats with Alzheimer's disease
por: Wang, Yan, et al.
Publicado: (2016)

IGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R
por: Qiao, Chenyang, et al.
Publicado: (2021)

Genistein suppresses the proliferation of telomerase‐negative cells
por: Lin, Chuan‐Chuan, et al.
Publicado: (2016)

Genistein treatment duration effects biomarkers of cell motility in human prostate
por: Zhang, Hu, et al.
Publicado: (2019)

Berberine inhibits EGFR signaling and enhances the antitumor effects of EGFR inhibitors in gastric cancer
por: Wang, Junxiong, et al.
Publicado: (2016)

Adenovirus-delivered CIAPIN1 small interfering RNA inhibits HCC growth in vitro and in vivo
por: Li, Xiaohua, et al.
Publicado: (2008)

Ectopic Expression of MiR-125a Inhibits the Proliferation and Metastasis of Hepatocellular Carcinoma by Targeting MMP11 and VEGF
por: Bi, Qian, et al.
Publicado: (2012)

Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR
por: Du, Feng, et al.
Publicado: (2019)

Genistein Suppresses Prostate Cancer Growth through Inhibition of Oncogenic MicroRNA-151
por: Chiyomaru, Takeshi, et al.
Publicado: (2012)

CXCL12-mediated HOXB5 overexpression facilitates Colorectal Cancer metastasis through transactivating CXCR4 and ITGB3
por: Feng, Weibo, et al.
Publicado: (2021)

MiR-218 Inhibits Invasion and Metastasis of Gastric Cancer by Targeting the Robo1 Receptor
por: Tie, Jun, et al.
Publicado: (2010)

Genistein suppresses aerobic glycolysis and induces hepatocellular carcinoma cell death
por: Li, Sainan, et al.
Publicado: (2017)

Genistein attenuates renal fibrosis in streptozotocin-induced diabetic rats
por: Jia, Qiang, et al.
Publicado: (2019)

Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells
por: Wang, Shulhn-Der, et al.
Publicado: (2014)

Suppression of lymphoma growth by the xenoestrogens bisphenol A and genistein
por: Yakimchuk, Konstantin, et al.
Publicado: (2018)

MicroRNA Let-7f Inhibits Tumor Invasion and Metastasis by Targeting MYH9 in Human Gastric Cancer
por: Liang, Shuli, et al.
Publicado: (2011)

O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit
por: Jiang, Mingzuo, et al.
Publicado: (2018)

Serum Concentration of Genistein, Luteolin and Colorectal Cancer Prognosis
por: Jiang, Ruijingfang, et al.
Publicado: (2019)

Correction: O-GlcNAcylation promotes colorectal cancer metastasis via the miR-101-O-GlcNAc/EZH2 regulatory feedback circuit
por: Jiang, Mingzuo, et al.
Publicado: (2019)

CXCR4 Inhibition Enhances Efficacy of FLT3 Inhibitors in FLT3-Mutated AML Augmented by Suppressed TGF-β Signaling
por: Kim, Bo-Reum, et al.
Publicado: (2020)

Effect of genistein on myocardial fibrosis in diabetic rats and its mechanism
por: Yang, Rui, et al.
Publicado: (2018)

Pharmacokinetics Interaction between Imatinib and Genistein in Rats
por: Wang, Zhe, et al.
Publicado: (2015)

Elevated O-GlcNAcylation promotes gastric cancer cells proliferation by modulating cell cycle related proteins and ERK 1/2 signaling
por: Jiang, Mingzuo, et al.
Publicado: (2016)

Interleukin 1β-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP
por: Dang, Yunzhi, et al.
Publicado: (2020)

Inhibition of castration-resistant prostate cancer growth by genistein through suppression of AKR1C3
por: Yu, Xiaoping, et al.
Publicado: (2023)

Soluble Flt-1 in AMI Patients Serum Inhibits Angiogenesis of Endothelial Progenitor Cells by Suppressing Akt and Erk’s Activity
por: Zhang, Lijie, et al.
Publicado: (2022)

GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3‑ITD acute myeloid leukemia
por: Xiao, Xinhua, et al.
Publicado: (2023)

MicroRNA-107, an oncogene microRNA that regulates tumour invasion and metastasis by targeting DICER1 in gastric cancer
por: Li, Xiaohua, et al.
Publicado: (2011)

miR-143 and miR-145 inhibit gastric cancer cell migration and metastasis by suppressing MYO6
por: Lei, Chao, et al.
Publicado: (2017)

The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer
por: Su, Linna, et al.
Publicado: (2014)

Non-digestible stachyose promotes bioavailability of genistein through inhibiting intestinal degradation and first-pass metabolism of genistein in mice
por: Lu, Yalong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_grrlodq0nr5epahcnfqh96q5mh