Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma

Medulloblastoma comprises four molecular subgroups of which Group 3 medulloblastoma is characterized by MYC amplification and MYC overexpression. Lymphoma cells expressing high levels of MYC are susceptible to apoptosis following treatment with inhibitors of mitosis. One of the key regulatory kinase...

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Detalles Bibliográficos
Autores principales: Diaz, Roberto Jose, Golbourn, Brian, Faria, Claudia, Picard, Daniel, Shih, David, Raynaud, Denis, Leadly, Michael, MacKenzie, Danielle, Bryant, Melissa, Bebenek, Matthew, Smith, Christian A., Taylor, Michael D., Huang, Annie, Rutka, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413659/
https://www.ncbi.nlm.nih.gov/pubmed/25739120

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