Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma

Mantle cell lymphoma (MCL) is an aggressive, incurable disease, characterized by a deregulated cell cycle. Chk1 and Wee1 are main regulators of cell cycle progression and recent data on solid tumors suggest that simultaneous inhibition of these proteins has a strong synergistic cytotoxic effect. The...

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Detalles Bibliográficos
Autores principales: Chilà, Rosaria, Basana, Alessandra, Lupi, Monica, Guffanti, Federica, Gaudio, Eugenio, Rinaldi, Andrea, Cascione, Luciano, Restelli, Valentina, Tarantelli, Chiara, Bertoni, Francesco, Damia, Giovanna, Carrassa, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413661/
https://www.ncbi.nlm.nih.gov/pubmed/25428911

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