FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

APOBEC cytidine deaminase activity is a major source of hypermutation in cancer. But previous studies have shown that the TC context signature of these enzymes is not observed in sizable fractions of cancers with overexpression of APOBEC, suggesting that cooperating factors that contribute to this m...

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Detalles Bibliográficos
Autores principales: Waters, Catherine E., Saldivar, Joshua C., Amin, Zaynab A., Schrock, Morgan S., Huebner, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413662/
https://www.ncbi.nlm.nih.gov/pubmed/25401976

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