Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans

Somatic hypermethylation of the O(6)-methylguanine-DNA methyltransferase gene (MGMT) was previously associated with G > A transition mutations in KRAS and TP53 in colorectal cancer (CRC). We tested the association of MGMT methylation with G > A mutations in KRAS and TP53 in 261 CRCs. Sixteen c...

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Detalles Bibliográficos
Autores principales: Alonso, Sergio, Dai, Yuichi, Yamashita, Kentaro, Horiuchi, Shina, Dai, Tomoko, Matsunaga, Akihiro, Sánchez-Muñoz, Rosa, Bilbao-Sieyro, Cristina, Díaz-Chico, Juan Carlos, Chernov, Andrei V., Strongin, Alex Y., Perucho, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Clinical Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413663/
https://www.ncbi.nlm.nih.gov/pubmed/25638164

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