The role of long non-coding RNAs in genome formatting and expression

Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation, and post-transcripti...

Descripción completa

Detalles Bibliográficos
Autores principales: Angrand, Pierre-Olivier, Vennin, Constance, Le Bourhis, Xuefen, Adriaenssens, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413816/
https://www.ncbi.nlm.nih.gov/pubmed/25972893
http://dx.doi.org/10.3389/fgene.2015.00165
Descripción
Sumario:Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation, and post-transcriptional control. Misregulation of lncRNAs expression has been found to be associated to cancer and other human disorders. Here, we review the different types of lncRNAs, their mechanisms of action on genome formatting and expression and emphasized on the multifaceted action of the H19 lncRNA.

Ejemplares similares