The role of long non-coding RNAs in genome formatting and expression

Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation, and post-transcripti...

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Autores principales: Angrand, Pierre-Olivier, Vennin, Constance, Le Bourhis, Xuefen, Adriaenssens, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413816/
https://www.ncbi.nlm.nih.gov/pubmed/25972893
http://dx.doi.org/10.3389/fgene.2015.00165
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author Angrand, Pierre-Olivier
Vennin, Constance
Le Bourhis, Xuefen
Adriaenssens, Eric
author_facet Angrand, Pierre-Olivier
Vennin, Constance
Le Bourhis, Xuefen
Adriaenssens, Eric
author_sort Angrand, Pierre-Olivier
collection PubMed
description Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation, and post-transcriptional control. Misregulation of lncRNAs expression has been found to be associated to cancer and other human disorders. Here, we review the different types of lncRNAs, their mechanisms of action on genome formatting and expression and emphasized on the multifaceted action of the H19 lncRNA.
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spelling pubmed-44138162015-05-13 The role of long non-coding RNAs in genome formatting and expression Angrand, Pierre-Olivier Vennin, Constance Le Bourhis, Xuefen Adriaenssens, Eric Front Genet Genetics Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential but having a pivotal role in numerous biological functions. Long non-coding RNAs act as regulators at different levels of gene expression including chromatin organization, transcriptional regulation, and post-transcriptional control. Misregulation of lncRNAs expression has been found to be associated to cancer and other human disorders. Here, we review the different types of lncRNAs, their mechanisms of action on genome formatting and expression and emphasized on the multifaceted action of the H19 lncRNA. Frontiers Media S.A. 2015-04-29 /pmc/articles/PMC4413816/ /pubmed/25972893 http://dx.doi.org/10.3389/fgene.2015.00165 Text en Copyright © 2015 Angrand, Vennin, Le Bourhis and Adriaenssens. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Angrand, Pierre-Olivier
Vennin, Constance
Le Bourhis, Xuefen
Adriaenssens, Eric
The role of long non-coding RNAs in genome formatting and expression
title The role of long non-coding RNAs in genome formatting and expression
title_full The role of long non-coding RNAs in genome formatting and expression
title_fullStr The role of long non-coding RNAs in genome formatting and expression
title_full_unstemmed The role of long non-coding RNAs in genome formatting and expression
title_short The role of long non-coding RNAs in genome formatting and expression
title_sort role of long non-coding rnas in genome formatting and expression
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413816/
https://www.ncbi.nlm.nih.gov/pubmed/25972893
http://dx.doi.org/10.3389/fgene.2015.00165
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