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Quantitative analysis of RNA-protein interactions on a massively parallel array for mapping biophysical and evolutionary landscapes

RNA-protein interactions drive fundamental biological processes and are targets for molecular engineering, yet quantitative and comprehensive understanding of the sequence determinants of affinity remains limited. Here we repurpose a high-throughput sequencing instrument to quantitatively measure bi...

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Detalles Bibliográficos
Autores principales:	Buenrostro, Jason D., Chircus, Lauren M., Araya, Carlos L., Layton, Curtis J., Chang, Howard Y., Snyder, Michael P., Greenleaf, William J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414031/ https://www.ncbi.nlm.nih.gov/pubmed/24727714 http://dx.doi.org/10.1038/nbt.2880

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