The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3

The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein, a component of Trans-Golgi Network (TGN), has been defined as a “first-in-class Golgi oncoprotein” and characterized as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is commonly amplified in several solid tumor...

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Autores principales: Sechi, Stefano, Frappaolo, Anna, Belloni, Giorgio, Colotti, Gianni, Giansanti, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414131/
https://www.ncbi.nlm.nih.gov/pubmed/25691054
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author Sechi, Stefano
Frappaolo, Anna
Belloni, Giorgio
Colotti, Gianni
Giansanti, Maria Grazia
author_facet Sechi, Stefano
Frappaolo, Anna
Belloni, Giorgio
Colotti, Gianni
Giansanti, Maria Grazia
author_sort Sechi, Stefano
collection PubMed
description The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein, a component of Trans-Golgi Network (TGN), has been defined as a “first-in-class Golgi oncoprotein” and characterized as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is commonly amplified in several solid tumors. Furthermore this protein has been associated with poor prognosis in many cancers. Highly conserved from yeast to humans, GOLPH3 provides an essential function in vesicle trafficking and Golgi structure. Recent data have also implicated this oncoprotein in regulation of cytokinesis, modulation of mitochondrial mass and cellular response to DNA damage. A minute dissection of the molecular pathways that require GOLPH3 protein will be helpful to develop new therapeutic cancer strategies.
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spelling pubmed-44141312015-05-08 The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3 Sechi, Stefano Frappaolo, Anna Belloni, Giorgio Colotti, Gianni Giansanti, Maria Grazia Oncotarget Review The highly conserved Golgi phosphoprotein 3 (GOLPH3) protein, a component of Trans-Golgi Network (TGN), has been defined as a “first-in-class Golgi oncoprotein” and characterized as a Phosphatidylinositol 4-phosphate [PI(4)P] effector at the Golgi. GOLPH3 is commonly amplified in several solid tumors. Furthermore this protein has been associated with poor prognosis in many cancers. Highly conserved from yeast to humans, GOLPH3 provides an essential function in vesicle trafficking and Golgi structure. Recent data have also implicated this oncoprotein in regulation of cytokinesis, modulation of mitochondrial mass and cellular response to DNA damage. A minute dissection of the molecular pathways that require GOLPH3 protein will be helpful to develop new therapeutic cancer strategies. Impact Journals LLC 2015-01-23 /pmc/articles/PMC4414131/ /pubmed/25691054 Text en Copyright: © 2015 Sechi et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Sechi, Stefano
Frappaolo, Anna
Belloni, Giorgio
Colotti, Gianni
Giansanti, Maria Grazia
The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3
title The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3
title_full The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3
title_fullStr The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3
title_full_unstemmed The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3
title_short The multiple cellular functions of the oncoprotein Golgi phosphoprotein 3
title_sort multiple cellular functions of the oncoprotein golgi phosphoprotein 3
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414131/
https://www.ncbi.nlm.nih.gov/pubmed/25691054
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