p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia

MYC-induced T-ALL exhibit oncogene addiction. Addiction to MYC is a consequence of both cell-autonomous mechanisms, such as proliferative arrest, cellular senescence, and apoptosis, as well as non-cell autonomous mechanisms, such as shutdown of angiogenesis, and recruitment of immune effectors. Here...

Descripción completa

Detalles Bibliográficos
Autores principales: Yetil, Alper, Anchang, Benedict, Gouw, Arvin M., Adam, Stacey J., Zabuawala, Tahera, Parameswaran, Ramya, van Riggelen, Jan, Plevritis, Sylvia, Felsher, Dean W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414137/
https://www.ncbi.nlm.nih.gov/pubmed/25784651

Ejemplares similares

Ejemplares similares