DNA methylome and transcriptome sequencing in human ovarian granulosa cells links age-related changes in gene expression to gene body methylation and 3ʹ-end GC density

Diminished ovarian function occurs early and is a primary cause for age-related decline in female fertility; however, its underlying mechanism remains unclear. This study investigated the roles that genome and epigenome structure play in age-related changes in gene expression and ovarian function, u...

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Detalles Bibliográficos
Autores principales: Yu, Bo, Russanova, Valya R., Gravina, Silvia, Hartley, Stephen, Mullikin, James C., Ignezweski, Alice, Graham, James, Segars, James H., DeCherney, Alan H., Howard, Bruce H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Gerotarget (Focus on Aging): Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414142/
https://www.ncbi.nlm.nih.gov/pubmed/25682867

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