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Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer

Antibody targeting of tumor-associated vasculature is a promising therapeutic approach in human cancer; however, a specific cell membrane marker for endothelial cells of tumor vasculature has not been discovered yet. Endoglin (CD105) is a cell-surface glycoprotein most recently identified as an opti...

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Detalles Bibliográficos
Autores principales: Fonsatti, Ester, Maio, Michele
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC441416/
https://www.ncbi.nlm.nih.gov/pubmed/15193152
http://dx.doi.org/10.1186/1479-5876-2-18
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author Fonsatti, Ester
Maio, Michele
author_facet Fonsatti, Ester
Maio, Michele
author_sort Fonsatti, Ester
collection PubMed
description Antibody targeting of tumor-associated vasculature is a promising therapeutic approach in human cancer; however, a specific cell membrane marker for endothelial cells of tumor vasculature has not been discovered yet. Endoglin (CD105) is a cell-surface glycoprotein most recently identified as an optimal indicator of proliferation of human endothelial cells. The finding that CD105 is over-expressed on vascular endothelium in angiogenetic tissues has prompted several pre-clinical studies designed to get a deeper understanding on the role of CD105 in angiogenesis, and to evaluate the most appropriate clinical setting(s) to utilize CD105 as a therapeutic target. In this review, the foreseeable clinical applications of CD105 in human cancer are discussed.
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spelling pubmed-4414162004-07-02 Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer Fonsatti, Ester Maio, Michele J Transl Med Review Antibody targeting of tumor-associated vasculature is a promising therapeutic approach in human cancer; however, a specific cell membrane marker for endothelial cells of tumor vasculature has not been discovered yet. Endoglin (CD105) is a cell-surface glycoprotein most recently identified as an optimal indicator of proliferation of human endothelial cells. The finding that CD105 is over-expressed on vascular endothelium in angiogenetic tissues has prompted several pre-clinical studies designed to get a deeper understanding on the role of CD105 in angiogenesis, and to evaluate the most appropriate clinical setting(s) to utilize CD105 as a therapeutic target. In this review, the foreseeable clinical applications of CD105 in human cancer are discussed. BioMed Central 2004-06-11 /pmc/articles/PMC441416/ /pubmed/15193152 http://dx.doi.org/10.1186/1479-5876-2-18 Text en Copyright © 2004 Fonsatti and Maio; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
spellingShingle Review
Fonsatti, Ester
Maio, Michele
Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer
title Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer
title_full Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer
title_fullStr Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer
title_full_unstemmed Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer
title_short Highlights on endoglin (CD105): from basic findings towards clinical applications in human cancer
title_sort highlights on endoglin (cd105): from basic findings towards clinical applications in human cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC441416/
https://www.ncbi.nlm.nih.gov/pubmed/15193152
http://dx.doi.org/10.1186/1479-5876-2-18
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