C-terminal domain of SMYD3 serves as a unique HSP90-regulated motif in oncogenesis

The SMYD3 histone methyl transferase (HMTase) and the nuclear chaperone, HSP90, have been independently implicated as proto-oncogenes in several human malignancies. We show that a degenerate tetratricopeptide repeat (TPR)-like domain encoded in the SMYD3 C-terminal domain (CTD) mediates physical int...

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Detalles Bibliográficos
Autores principales: Brown, Mark A., Foreman, Kenneth, Harriss, June, Das, Chhaya, Zhu, Li, Edwards, Melissa, Shaaban, Salam, Tucker, Haley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414169/
https://www.ncbi.nlm.nih.gov/pubmed/25738358

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