SKI2162, an inhibitor of the TGF-β type I receptor (ALK5), inhibits radiation-induced fibrosis in mice

Here we demonstrated that SKI2162, a small-molecule inhibitor of the TGF-β type I receptor (ALK5), prevented radiation-induced fibrosis (RIF) in mice. SKI2162 inhibited phosphorylation of Smad and induction of RIF-related genes in vitro. In RIF a mouse model, SKI2162 reduced late skin reactions and...

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Detalles Bibliográficos
Autores principales: Park, Jin-hong, Ryu, Seung-Hee, Choi, Eun Kyung, Ahn, Seung Do, Park, Euisun, Choi, Kyung-Chul, Lee, Sang-wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414180/
https://www.ncbi.nlm.nih.gov/pubmed/25686821

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