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Mucin1 shifts Smad3 signaling from the tumor-suppressive pSmad3C/p21(WAF1) pathway to the oncogenic pSmad3L/c-Myc pathway by activating JNK in human hepatocellular carcinoma cells
Mucin1 (MUC1) is a transmembrane glycoprotein that acts as an oncogene in human hepatic tumorigenesis. Hepatocellular carcinoma (HCC) cells often gain advantage by reducing the tumor-suppressive activity of transforming growth factor beta (TGF-β) together with stimulation of its oncogenic activity a...
Autores principales: | Li, Qiongshu, Liu, Guomu, Yuan, Hongyan, Wang, Juan, Guo, Yingying, Chen, Tanxiu, Zhai, Ruiping, Shao, Dan, Ni, Weihua, Tai, Guixiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414187/ https://www.ncbi.nlm.nih.gov/pubmed/25714018 |
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