PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects

The protein phosphatase 2A (PP2A) is a key tumor suppressor which has emerged as a novel molecular target in some human cancers. Here, we show that PP2A inhibition is a common event in breast cancer and identified PP2A phosphorylation and deregulation SET and CIP2A as molecular contributing mechanis...

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Detalles Bibliográficos
Autores principales: Rincón, Raúl, Cristóbal, Ion, Zazo, Sandra, Arpí, Oriol, Menéndez, Silvia, Manso, Rebeca, Lluch, Ana, Eroles, Pilar, Rovira, Ana, Albanell, Joan, García-Foncillas, Jesús, Madoz-Gúrpide, Juan, Rojo, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414191/
https://www.ncbi.nlm.nih.gov/pubmed/25726524

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