Cargando…

Safety and biodistribution of (111)In-amatuximab in patients with mesothelin expressing cancers using Single Photon Emission Computed Tomography-Computed Tomography (SPECT-CT) imaging

Amatuximab is a chimeric high-affinity monoclonal IgG1/k antibody targeting mesothelin that is being developed for treatment of mesothelin-expressing cancers. Considering the ongoing clinical development of amatuximab in these cancers, our objective was to characterize the biodistribution, and dosim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lindenberg, Liza, Thomas, Anish, Adler, Stephen, Mena, Esther, Kurdziel, Karen, Maltzman, Julia, Wallin, Bruce, Hoffman, Kimberly, Pastan, Ira, Paik, Chang Hum, Choyke, Peter, Hassan, Raffit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Clinical Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414206/ https://www.ncbi.nlm.nih.gov/pubmed/25756664

Ejemplares similares

Amatuximab and novel agents targeting mesothelin for solid tumors
por: Baldo, Paolo, et al.
Publicado: (2017)

Mesothelin blockage by Amatuximab suppresses cell invasiveness, enhances gemcitabine sensitivity and regulates cancer cell stemness in mesothelin-positive pancreatic cancer cells
por: Matsuzawa, Fumihiko, et al.
Publicado: (2021)

Targeting mesothelin in ovarian cancer
por: Ghafoor, Azam, et al.
Publicado: (2018)

Phase I study of amatuximab, a novel monoclonal antibody to mesothelin, in Japanese patients with advanced solid tumors
por: Fujisaka, Yasuhito, et al.
Publicado: (2014)

The anti-mesothelin monoclonal antibody amatuximab enhances the anti-tumor effect of gemcitabine against mesothelin-high expressing pancreatic cancer cells in a peritoneal metastasis mouse model
por: Mizukami, Tatsuzo, et al.
Publicado: (2018)

Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin
por: Liu, Xiufen, et al.
Publicado: (2022)

Biodistribution and radiation dosimetry of multiple tracers on total-body positron emission tomography/computed tomography
por: Li, Lianghua, et al.
Publicado: (2023)

High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis
por: Thomas, Anish, et al.
Publicado: (2015)

Dual B- and T-cell de-immunization of recombinant immunotoxin targeting mesothelin with high cytotoxic activity
por: Mazor, Ronit, et al.
Publicado: (2016)

New High Affinity Monoclonal Antibodies Recognize Non-Overlapping Epitopes On Mesothelin For Monitoring And Treating Mesothelioma
por: Zhang, Yi-Fan, et al.
Publicado: (2015)

First-in-human phase 0 study of (111)In-CHX-A”-DTPA trastuzumab for HER2 tumor imaging
por: Kurdziel, KA, et al.
Publicado: (2018)

Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies
por: Zhan, Jingyu, et al.
Publicado: (2023)

Megakaryocytic Potentiating Factor and Mature Mesothelin Stimulate the Growth of a Lung Cancer Cell Line in the Peritoneal Cavity of Mice
por: Zhang, Jingli, et al.
Publicado: (2014)

Usefulness of single photon emission computed tomography (SPECT)/computed tomography and radioguided surgery in a patient with recurrent pheochromocytoma
por: Uña-Gorospe, Jon Andoni, et al.
Publicado: (2013)

Modulating Mesothelin Shedding to Improve Therapy
por: Zhang, Yujian, et al.
Publicado: (2012)

Incidental findings on single‐photon emission computed tomography/computed tomography (SPECT/CT) lymphoscintigraphy in breast cancer: the proposed Westmead SPECT/CT incidental findings classification
por: Quah, Gaik Si, et al.
Publicado: (2022)

Deep Learning Based Staging of Bone Lesions From Computed Tomography Scans
por: MASOUDI, SAMIRA, et al.
Publicado: (2021)

CA125 suppresses amatuximab immune-effector function and elevated serum levels are associated with reduced clinical response in first line mesothelioma patients
por: Nicolaides, Nicholas C., et al.
Publicado: (2018)

Spectrum of single photon emission computed tomography/computed tomography findings in patients with parathyroid adenomas
por: Chakraborty, Dhritiman, et al.
Publicado: (2011)

Methylation-Associated Partial Down-Regulation of Mesothelin Causes Resistance to Anti-Mesothelin Immunotoxins in a Pancreatic Cancer Cell Line
por: Hollevoet, Kevin, et al.
Publicado: (2015)

Role of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Diagnostic Evaluation of Carcinoma Urinary Bladder: Comparison with Computed Tomography
por: Chakraborty, Dhritiman, et al.
Publicado: (2014)

Osseous vitality in single photon emission computed tomography/computed tomography (SPECT/CT) after balloon tibioplasty of the tibial plateau: a case series
por: Jentzsch, Thorsten, et al.
Publicado: (2015)

The Use of Single-Photon-Emission Computed Tomography (SPECT) for the Evaluation of Painful Ankle Arthroplasties
por: Refaie, Ramsay, et al.
Publicado: (2020)

Hybrid Single Photon Emission Computed Tomography/Computed Tomography Sulphur Colloid Scintigraphy in Focal Nodular Hyperplasia
por: Bhoil, Amit, et al.
Publicado: (2013)

Utility of single photon emission computed tomography/computed tomography imaging in evaluation of chronic low back pain
por: Harisankar, Chidambaram Natrajan Balasubramanian, et al.
Publicado: (2012)

Dose escalation biodistribution, positron emission tomography/computed tomography imaging and dosimetry of a highly specific radionuclide-labeled non-blocking nanobody
por: Yang, Yanling, et al.
Publicado: (2021)

Multiple proteases are involved in mesothelin shedding by cancer cells
por: Liu, Xiufen, et al.
Publicado: (2020)

Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram
por: Carey, Paul D, et al.
Publicado: (2004)

A study to improve the image quality in low-dose computed tomography (SPECT) using filtration
por: Kheruka, SC, et al.
Publicado: (2011)

Targeting butyrylcholinesterase for preclinical single photon emission computed tomography (SPECT) imaging of Alzheimer's disease
por: DeBay, Drew R., et al.
Publicado: (2017)

Myocardial Perfusion by Coronary Computed Tomography in the Evaluation of Myocardial Ischemia: Simultaneous Stress Protocol with SPECT
por: Ker, Wilter dos Santos, et al.
Publicado: (2019)

Complementary role of computed tomography angiography with fixed perfusion defects on SPECT myocardial perfusion imaging
por: Abazid, Rami M., et al.
Publicado: (2022)

Artificial intelligence in single photon emission computed tomography (SPECT) imaging: a narrative review
por: Shao, Wenyi, et al.
Publicado: (2021)

Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Findings in Nodular Hepatic and Splenic Sarcoidosis
por: Agrawal, Kanhaiyalal, et al.
Publicado: (2014)

Lymphoscintigraphy combined with single-photon emission computed tomography-computed tomography (SPECT-CT): A very effective imaging approach for identification of the site of leak in postoperative chylothorax
por: Das, Jayanta, et al.
Publicado: (2015)

Skull base osteomyelitis in otitis externa: The utility of triphasic and single photon emission computed tomography/computed tomography bone scintigraphy
por: Chakraborty, Dhritiman, et al.
Publicado: (2013)

Development of Highly Effective Anti-Mesothelin hYP218 Chimeric Antigen Receptor T Cells With Increased Tumor Infiltration and Persistence for Treating Solid Tumors
por: Tomar, Sakshi, et al.
Publicado: (2022)

The Comparison of Computed Tomography Perfusion, Contrast-Enhanced Computed Tomography and Positron-Emission Tomography/Computed Tomography for the Detection of Primary Esophageal Carcinoma
por: Genc, Berhan, et al.
Publicado: (2016)

Patterns of brown fat uptake of 18F-fluorodeoxyglucose in positron emission tomography/computed tomography scan
por: Chakraborty, Dhritiman, et al.
Publicado: (2015)

Role of single photon emission computed tomography/computed tomography in diagnostic iodine-131 scintigraphy before initial radioiodine ablation in differentiated thyroid cancer
por: Agrawal, Kanhaiyalal, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kg11c76punm2ftedo4cqu5hvua