GLI2 inhibition abrogates human leukemia stem cell dormancy

BACKGROUND: Dormant leukemia stem cells (LSC) promote therapeutic resistance and leukemic progression as a result of unbridled activation of stem cell gene expression programs. Thus, we hypothesized that 1) deregulation of the hedgehog (Hh) stem cell self-renewal and cell cycle regulatory pathway wo...

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Detalles Bibliográficos
Autores principales: Sadarangani, Anil, Pineda, Gabriel, Lennon, Kathleen M, Chun, Hye-Jung, Shih, Alice, Schairer, Annelie E, Court, Angela C, Goff, Daniel J, Prashad, Sacha L, Geron, Ifat, Wall, Russell, McPherson, John D, Moore, Richard A, Pu, Minya, Bao, Lei, Jackson-Fisher, Amy, Munchhof, Michael, VanArsdale, Todd, Reya, Tannishtha, Morris, Sheldon R, Minden, Mark D, Messer, Karen, Mikkola, Hanna KA, Marra, Marco A, Hudson, Thomas J, Jamieson, Catriona HM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414375/
https://www.ncbi.nlm.nih.gov/pubmed/25889765
http://dx.doi.org/10.1186/s12967-015-0453-9

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