The angiotensin converting enzyme inhibitor, captopril, prevents the hyperactivity and impulsivity of neurokinin-1 receptor gene ‘knockout’ mice: Sex differences and implications for the treatment of attention deficit hyperactivity disorder

Mice lacking functional neurokinin-1 receptors (NK1R−/−) display behavioural abnormalities resembling attention deficit hyperactivity disorder (ADHD): locomotor hyperactivity, impulsivity and inattentiveness. The preferred ligand for NK1R, substance P, is metabolised by angiotensin converting enzyme...

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Detalles Bibliográficos
Autores principales: Porter, Ashley J., Pillidge, Katharine, Grabowska, Ewelina M., Stanford, S. Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414389/
https://www.ncbi.nlm.nih.gov/pubmed/25703442
http://dx.doi.org/10.1016/j.euroneuro.2015.01.013

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