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Defining functional signatures of dysbiosis in periodontitis progression
Periodontitis is a common inflammatory disease that leads to tooth loss and has been linked to cardiovascular disease and diabetes mellitus. The periodontal microbiome is highly diverse, and metatranscriptomic studies have indicated that the genes that are expressed by the microbiota are more releva...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414443/ https://www.ncbi.nlm.nih.gov/pubmed/25926890 http://dx.doi.org/10.1186/s13073-015-0165-z |
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author | Wang, Gary P |
author_facet | Wang, Gary P |
author_sort | Wang, Gary P |
collection | PubMed |
description | Periodontitis is a common inflammatory disease that leads to tooth loss and has been linked to cardiovascular disease and diabetes mellitus. The periodontal microbiome is highly diverse, and metatranscriptomic studies have indicated that the genes that are expressed by the microbiota are more relevant than the microbial composition in the pathogenesis of periodontitis. A recent study of early metabolic activities in the dysbiotic microbiome reveals a functional signature that distinguishes periodontal sites that will become inflamed, supporting the idea that microbial communities as a whole drive disease progression. |
format | Online Article Text |
id | pubmed-4414443 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44144432015-04-30 Defining functional signatures of dysbiosis in periodontitis progression Wang, Gary P Genome Med Research Highlight Periodontitis is a common inflammatory disease that leads to tooth loss and has been linked to cardiovascular disease and diabetes mellitus. The periodontal microbiome is highly diverse, and metatranscriptomic studies have indicated that the genes that are expressed by the microbiota are more relevant than the microbial composition in the pathogenesis of periodontitis. A recent study of early metabolic activities in the dysbiotic microbiome reveals a functional signature that distinguishes periodontal sites that will become inflamed, supporting the idea that microbial communities as a whole drive disease progression. BioMed Central 2015-04-27 /pmc/articles/PMC4414443/ /pubmed/25926890 http://dx.doi.org/10.1186/s13073-015-0165-z Text en © Wang; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise credited. |
spellingShingle | Research Highlight Wang, Gary P Defining functional signatures of dysbiosis in periodontitis progression |
title | Defining functional signatures of dysbiosis in periodontitis progression |
title_full | Defining functional signatures of dysbiosis in periodontitis progression |
title_fullStr | Defining functional signatures of dysbiosis in periodontitis progression |
title_full_unstemmed | Defining functional signatures of dysbiosis in periodontitis progression |
title_short | Defining functional signatures of dysbiosis in periodontitis progression |
title_sort | defining functional signatures of dysbiosis in periodontitis progression |
topic | Research Highlight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414443/ https://www.ncbi.nlm.nih.gov/pubmed/25926890 http://dx.doi.org/10.1186/s13073-015-0165-z |
work_keys_str_mv | AT wanggaryp definingfunctionalsignaturesofdysbiosisinperiodontitisprogression |