Peptides of Presenilin-1 Bind the Amyloid Precursor Protein Ectodomain and Offer a Novel and Specific Therapeutic Approach to Reduce ß-Amyloid in Alzheimer’s Disease

β-Amyloid (Aβ) accumulation in the brain is widely accepted to be critical to the development of Alzheimer’s disease (AD). Current efforts at reducing toxic Aβ40 or 42 have largely focused on modulating γ-secretase activity to produce shorter, less toxic Aβ, while attempting to spare other secretase...

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Detalles Bibliográficos
Autores principales: Dewji, Nazneen N., Singer, S. Jonathan, Masliah, Eliezer, Rockenstein, Edward, Kim, Mihyun, Harber, Martha, Horwood, Taylor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414571/
https://www.ncbi.nlm.nih.gov/pubmed/25923432
http://dx.doi.org/10.1371/journal.pone.0122451

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