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Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects

PURPOSE: This study evaluated the mechanical and structural properties of biphasic calcium phosphate (BCP) blocks processed using a modified extrusion method, and assessed their in vivo effectiveness using a rabbit calvarial defect model. METHODS: BCP blocks with three distinct ratios of hydroxyapat...

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Autores principales: Lim, Hyun-Chang, Song, Kyung-Ho, You, Hoon, Lee, Jung-Seok, Jung, Ui-Won, Kim, Suk-Young, Choi, Seong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Periodontology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415001/
https://www.ncbi.nlm.nih.gov/pubmed/25932338
http://dx.doi.org/10.5051/jpis.2015.45.2.46
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author Lim, Hyun-Chang
Song, Kyung-Ho
You, Hoon
Lee, Jung-Seok
Jung, Ui-Won
Kim, Suk-Young
Choi, Seong-Ho
author_facet Lim, Hyun-Chang
Song, Kyung-Ho
You, Hoon
Lee, Jung-Seok
Jung, Ui-Won
Kim, Suk-Young
Choi, Seong-Ho
author_sort Lim, Hyun-Chang
collection PubMed
description PURPOSE: This study evaluated the mechanical and structural properties of biphasic calcium phosphate (BCP) blocks processed using a modified extrusion method, and assessed their in vivo effectiveness using a rabbit calvarial defect model. METHODS: BCP blocks with three distinct ratios of hydroxyapatite (HA):tricalcium phosphate (TCP) were produced using a modified extrusion method:HA8 (8%:92%), HA48 (48%:52%), and HA80 (80%:20%). The blocks were examined using scanning electron microscopy, X-ray diffractometry, and a universal test machine. Four circular defects 8 mm in diameter were made in 12 rabbits. One defect in each animal served as a control, and the other three defects received the BCP blocks. The rabbits were sacrificed at either two weeks (n=6) or eight weeks (n=6) postoperatively. RESULTS: The pore size, porosity, and compressive strength of the three types of bone block were 140-170 µm, >70%, and 4-9 MPa, respectively. Histologic and histomorphometric observations revealed that the augmented space was well maintained, but limited bone formation was observed around the defect base and defect margins. No significant differences were found in the amount of new bone formation, graft material resorption, or bone infiltration among the three types of BCP block at either of the postoperative healing points. CONCLUSIONS: Block bone substitutes with three distinct compositions (i.e., HA:TCP ratios) processed by a modified extrusion method exhibited limited osteoconductive potency, but excellent space-maintaining capability. Further investigations are required to improve the processing method. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-44150012015-04-30 Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects Lim, Hyun-Chang Song, Kyung-Ho You, Hoon Lee, Jung-Seok Jung, Ui-Won Kim, Suk-Young Choi, Seong-Ho J Periodontal Implant Sci Research Article PURPOSE: This study evaluated the mechanical and structural properties of biphasic calcium phosphate (BCP) blocks processed using a modified extrusion method, and assessed their in vivo effectiveness using a rabbit calvarial defect model. METHODS: BCP blocks with three distinct ratios of hydroxyapatite (HA):tricalcium phosphate (TCP) were produced using a modified extrusion method:HA8 (8%:92%), HA48 (48%:52%), and HA80 (80%:20%). The blocks were examined using scanning electron microscopy, X-ray diffractometry, and a universal test machine. Four circular defects 8 mm in diameter were made in 12 rabbits. One defect in each animal served as a control, and the other three defects received the BCP blocks. The rabbits were sacrificed at either two weeks (n=6) or eight weeks (n=6) postoperatively. RESULTS: The pore size, porosity, and compressive strength of the three types of bone block were 140-170 µm, >70%, and 4-9 MPa, respectively. Histologic and histomorphometric observations revealed that the augmented space was well maintained, but limited bone formation was observed around the defect base and defect margins. No significant differences were found in the amount of new bone formation, graft material resorption, or bone infiltration among the three types of BCP block at either of the postoperative healing points. CONCLUSIONS: Block bone substitutes with three distinct compositions (i.e., HA:TCP ratios) processed by a modified extrusion method exhibited limited osteoconductive potency, but excellent space-maintaining capability. Further investigations are required to improve the processing method. GRAPHICAL ABSTRACT: [Image: see text] Korean Academy of Periodontology 2015-04 2015-04-29 /pmc/articles/PMC4415001/ /pubmed/25932338 http://dx.doi.org/10.5051/jpis.2015.45.2.46 Text en Copyright © 2015 Korean Academy of Periodontology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).
spellingShingle Research Article
Lim, Hyun-Chang
Song, Kyung-Ho
You, Hoon
Lee, Jung-Seok
Jung, Ui-Won
Kim, Suk-Young
Choi, Seong-Ho
Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects
title Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects
title_full Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects
title_fullStr Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects
title_full_unstemmed Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects
title_short Effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects
title_sort effectiveness of biphasic calcium phosphate block bone substitutes processed using a modified extrusion method in rabbit calvarial defects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415001/
https://www.ncbi.nlm.nih.gov/pubmed/25932338
http://dx.doi.org/10.5051/jpis.2015.45.2.46
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