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Histomorphometric analysis of microcrack healing after the installation of mini-implants
PURPOSE: The goal of this study was to investigate the histomorphometric characteristics of the healing process of microcracks in the cortical bone after the installation of mini-implants (MIs). METHODS: Self-drilling MIs were inserted into the tibial diaphysis of twelve adult male New Zealand rabbi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Academy of Periodontology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415003/ https://www.ncbi.nlm.nih.gov/pubmed/25932340 http://dx.doi.org/10.5051/jpis.2015.45.2.62 |
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author | Shin, Soobin Park, Pan-Soo Baek, Seung-Hak Yang, Il-Hyung |
author_facet | Shin, Soobin Park, Pan-Soo Baek, Seung-Hak Yang, Il-Hyung |
author_sort | Shin, Soobin |
collection | PubMed |
description | PURPOSE: The goal of this study was to investigate the histomorphometric characteristics of the healing process of microcracks in the cortical bone after the installation of mini-implants (MIs). METHODS: Self-drilling MIs were inserted into the tibial diaphysis of twelve adult male New Zealand rabbits. Four MIs per rabbit were placed randomly. The animals were divided into four groups according to the length of the healing period: group A was sacrificed immediately, group B was sacrificed after one week, group C was sacrificed after two weeks, and group D was sacrificed after four weeks. Cortical bone thickness was measured using micro-computed tomography, and histomorphometric analyses of the cumulative length of the microcracks (CLCr) and the total number of microcracks (NCr) were performed using hematoxylin and eosin staining. RESULTS: The microcracks were radially and concentrically aligned in the peri-MI bone. The CLCr decreased significantly one week after the surgery, mainly due to healing of the concentrically aligned microcracks. The CLCr showed another significant decrease from two weeks after the surgery to four weeks after the surgery, mainly reflecting healing of the radially aligned microcracks. A statistically significant decrease in the NCr occurred as the microcracks healed from zero weeks to two weeks. However, no significant difference in the NCr was found between groups C and D. CONCLUSIONS: In order to improve the primary stability of MIs, delayed loading and a healing period of a certain length are recommended to ensure the optimal healing of microcracks and bone remodeling. GRAPHICAL ABSTRACT: [Image: see text] |
format | Online Article Text |
id | pubmed-4415003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Academy of Periodontology |
record_format | MEDLINE/PubMed |
spelling | pubmed-44150032015-04-30 Histomorphometric analysis of microcrack healing after the installation of mini-implants Shin, Soobin Park, Pan-Soo Baek, Seung-Hak Yang, Il-Hyung J Periodontal Implant Sci Research Article PURPOSE: The goal of this study was to investigate the histomorphometric characteristics of the healing process of microcracks in the cortical bone after the installation of mini-implants (MIs). METHODS: Self-drilling MIs were inserted into the tibial diaphysis of twelve adult male New Zealand rabbits. Four MIs per rabbit were placed randomly. The animals were divided into four groups according to the length of the healing period: group A was sacrificed immediately, group B was sacrificed after one week, group C was sacrificed after two weeks, and group D was sacrificed after four weeks. Cortical bone thickness was measured using micro-computed tomography, and histomorphometric analyses of the cumulative length of the microcracks (CLCr) and the total number of microcracks (NCr) were performed using hematoxylin and eosin staining. RESULTS: The microcracks were radially and concentrically aligned in the peri-MI bone. The CLCr decreased significantly one week after the surgery, mainly due to healing of the concentrically aligned microcracks. The CLCr showed another significant decrease from two weeks after the surgery to four weeks after the surgery, mainly reflecting healing of the radially aligned microcracks. A statistically significant decrease in the NCr occurred as the microcracks healed from zero weeks to two weeks. However, no significant difference in the NCr was found between groups C and D. CONCLUSIONS: In order to improve the primary stability of MIs, delayed loading and a healing period of a certain length are recommended to ensure the optimal healing of microcracks and bone remodeling. GRAPHICAL ABSTRACT: [Image: see text] Korean Academy of Periodontology 2015-04 2015-04-29 /pmc/articles/PMC4415003/ /pubmed/25932340 http://dx.doi.org/10.5051/jpis.2015.45.2.62 Text en Copyright © 2015 Korean Academy of Periodontology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/). |
spellingShingle | Research Article Shin, Soobin Park, Pan-Soo Baek, Seung-Hak Yang, Il-Hyung Histomorphometric analysis of microcrack healing after the installation of mini-implants |
title | Histomorphometric analysis of microcrack healing after the installation of mini-implants |
title_full | Histomorphometric analysis of microcrack healing after the installation of mini-implants |
title_fullStr | Histomorphometric analysis of microcrack healing after the installation of mini-implants |
title_full_unstemmed | Histomorphometric analysis of microcrack healing after the installation of mini-implants |
title_short | Histomorphometric analysis of microcrack healing after the installation of mini-implants |
title_sort | histomorphometric analysis of microcrack healing after the installation of mini-implants |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415003/ https://www.ncbi.nlm.nih.gov/pubmed/25932340 http://dx.doi.org/10.5051/jpis.2015.45.2.62 |
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