Cargando…

Synthesis and Potent Antimalarial Activity of Kalihinol B

[Image: see text] Of the 50+ kalihinane diterpenoids reported to date, only five had been tested for antimalarial activity, in spite of the fact that kalihinol A is the most potent among the members of the larger family of antimalarial isocyanoterpenes. We have validated a strategy designed to acces...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daub, Mary Elisabeth, Prudhomme, Jacques, Le Roch, Karine, Vanderwal, Christopher D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415034/ https://www.ncbi.nlm.nih.gov/pubmed/25815413 http://dx.doi.org/10.1021/jacs.5b01152

Ejemplares similares

Antimalarial Properties of Simplified Kalihinol Analogues
por: Daub, Mary Elisabeth, et al.
Publicado: (2017)

High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery
por: Cervantes, Serena, et al.
Publicado: (2009)

An Enantiospecific Synthesis of Isoneoamphilectane Confirms Its Strained Tricyclic Structure
por: Dwulet, Natalie C., et al.
Publicado: (2023)

Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones
por: Clark, Robert D., et al.
Publicado: (2020)

Diastereoselective Synthesis of Potent Antimalarial Cis-β-lactam Agents
por: Jarrahpour, Aliasghar, et al.
Publicado: (2019)

High content live cell imaging for the discovery of new antimalarial marine natural products
por: Cervantes, Serena, et al.
Publicado: (2012)

Potent Antimalarial Activity of Acriflavine In Vitro and In Vivo
por: Dana, Srikanta, et al.
Publicado: (2014)

Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies
por: Singh, Kamaljit, et al.
Publicado: (2013)

Chloroquine analogs as antimalarial candidates with potent in vitro and in vivo activity
por: Aguiar, Anna C.C., et al.
Publicado: (2018)

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties
por: Urgin, Karène, et al.
Publicado: (2017)

Structural Optimization of BIPPO Analogs as Potent Antimalarials
por: Zheng, Yang, et al.
Publicado: (2023)

Potent in vivo antimalarial activity of water-soluble artemisinin nano-preparations
por: Valissery, Praveesh, et al.
Publicado: (2020)

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis
por: Edwards, Rachel L., et al.
Publicado: (2017)

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
por: Richardson, Lachlan W., et al.
Publicado: (2022)

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
por: Kovada, Vadims, et al.
Publicado: (2023)

Ancient Chinese Methods Are Remarkably Effective for the Preparation of Artemisinin-Rich Extracts of Qing Hao with Potent Antimalarial Activity
por: Wright, Colin W., et al.
Publicado: (2010)

Enantioselective Synthesis of γ-Phenyl-γ-amino Vinyl Phosphonates and Sulfones and Their Application to the Synthesis of Novel Highly Potent Antimalarials
por: Aratikatla, Eswar K., et al.
Publicado: (2020)

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum
por: Krollenbrock, Alina, et al.
Publicado: (2021)

Synthesis and Antimalarial Activity of Mallatojaponin C and Related Compounds
por: Eaton, Alexander L., et al.
Publicado: (2016)

Synthesis and Antimalarial Activity of Novel Dihydro-Artemisinin Derivatives
por: Liu, Yang, et al.
Publicado: (2011)

Synthesis and Antimalarial Activities of New Hybrid Atokel Molecules
por: Li, Youzhi, et al.
Publicado: (2022)

Synthesis of New Triazolopyrazine Antimalarial Compounds
por: Johnson, Daniel J. G., et al.
Publicado: (2021)

Characterization of the Ubiquitylating Components of the Human Malaria Parasite’s Protein Degradation Pathway
por: Chung, Duk-Won D., et al.
Publicado: (2012)

In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids
por: Viira, Birgit, et al.
Publicado: (2016)

A Synthesis of the ABC Tricyclic Core of the Clionastatins Serves To Corroborate Their Proposed Structures
por: Tartakoff, Samuel S., et al.
Publicado: (2014)

Pyrazoleamide compounds are potent antimalarials that target Na(+) homeostasis in intraerythrocytic Plasmodium falciparum
por: Vaidya, Akhil B., et al.
Publicado: (2014)

New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication
por: Ueda, Youki, et al.
Publicado: (2013)

Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
por: Seck, Rokhyatou, et al.
Publicado: (2020)

An Efficient and Sustainable Synthesis of the Antimalarial Drug Tafenoquine
por: Kavthe, Rahul D., et al.
Publicado: (2022)

Diatretol, an α, α′-dioxo-diketopiperazine, is a potent in vitro and in vivo antimalarial
por: Ishiyama, Aki, et al.
Publicado: (2021)

World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility
por: Bacon, David J, et al.
Publicado: (2007)

The protein aggregation inhibitor YAT2150 has potent antimalarial activity in Plasmodium falciparum in vitro cultures
por: Bouzón-Arnáiz, Inés, et al.
Publicado: (2022)

The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum
por: Bunnik, Evelien M., et al.
Publicado: (2016)

Novel Synthetic Polyamines Have Potent Antimalarial Activities in vitro and in vivo by Decreasing Intracellular Spermidine and Spermine Concentrations
por: El Bissati, Kamal, et al.
Publicado: (2019)

Correction: New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication
por: Ueda, Youki, et al.
Publicado: (2013)

Marine Actinomycetes: A New Source of Compounds against the Human Malaria Parasite
por: Prudhomme, Jacques, et al.
Publicado: (2008)

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum
por: Lu, Xueqing Maggie, et al.
Publicado: (2017)

Antimalarial Activity of Piperine
por: Thiengsusuk, Artitaya, et al.
Publicado: (2018)

Pharmacophore modeling and 3D quantitative structure-activity relationship analysis of febrifugine analogues as potent antimalarial agent
por: Sen, Debanjan, et al.
Publicado: (2013)

7-N-Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome bc(1) Complex
por: Nguyen, William, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_7bf0gq7ud8avbhavg50a1kqs1d