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Neristatin 1 Provides Critical Insight into Bryostatin 1 Structure–Function Relationships
[Image: see text] Bryostatin 1, a complex macrocyclic lactone isolated from Bugula neritina, has been the subject of multiple clinical trials for cancer. Although it functions as an activator of protein kinase C (PKC) in vitro, bryostatin 1 paradoxically antagonizes most responses to the prototypica...
Autores principales: | Kedei, Noemi, Kraft, Matthew B., Keck, Gary E., Herald, Cherry L., Melody, Noeleen, Pettit, George R., Blumberg, Peter M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical
Society and American Society of Pharmacognosy
2015
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415049/ https://www.ncbi.nlm.nih.gov/pubmed/25808573 http://dx.doi.org/10.1021/acs.jnatprod.5b00094 |
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