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Neristatin 1 Provides Critical Insight into Bryostatin 1 Structure–Function Relationships

[Image: see text] Bryostatin 1, a complex macrocyclic lactone isolated from Bugula neritina, has been the subject of multiple clinical trials for cancer. Although it functions as an activator of protein kinase C (PKC) in vitro, bryostatin 1 paradoxically antagonizes most responses to the prototypica...

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Detalles Bibliográficos
Autores principales:	Kedei, Noemi, Kraft, Matthew B., Keck, Gary E., Herald, Cherry L., Melody, Noeleen, Pettit, George R., Blumberg, Peter M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society and American Society of Pharmacognosy 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415049/ https://www.ncbi.nlm.nih.gov/pubmed/25808573 http://dx.doi.org/10.1021/acs.jnatprod.5b00094

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