Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the incidence rate is low, SCAR sometimes can be life-threatening and leads to l...

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Detalles Bibliográficos
Autores principales: Dao, Ro-Lan, Su, Shih-Chi, Chung, Wen-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2015
Materias:
Current Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415181/
https://www.ncbi.nlm.nih.gov/pubmed/25938070
http://dx.doi.org/10.5415/apallergy.2015.5.2.59
Descripción
Sumario:Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the incidence rate is low, SCAR sometimes can be life-threatening and leads to lifelong sequelae. Many pharmacogenomic associations in immune and nonimmune related genes with the development of SCAR have been discovered recently and the pharmacogenetic tests have been applied to prevent specific drug-induced SCAR. In this review, we discuss the recent advances of pharmacogenomics in SCAR.

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