Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the incidence rate is low, SCAR sometimes can be life-threatening and leads to l...

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Autores principales: Dao, Ro-Lan, Su, Shih-Chi, Chung, Wen-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2015
Materias:
Current Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415181/
https://www.ncbi.nlm.nih.gov/pubmed/25938070
http://dx.doi.org/10.5415/apallergy.2015.5.2.59
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author Dao, Ro-Lan
Su, Shih-Chi
Chung, Wen-Hung
author_facet Dao, Ro-Lan
Su, Shih-Chi
Chung, Wen-Hung
author_sort Dao, Ro-Lan
collection PubMed
description Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the incidence rate is low, SCAR sometimes can be life-threatening and leads to lifelong sequelae. Many pharmacogenomic associations in immune and nonimmune related genes with the development of SCAR have been discovered recently and the pharmacogenetic tests have been applied to prevent specific drug-induced SCAR. In this review, we discuss the recent advances of pharmacogenomics in SCAR.
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spelling pubmed-44151812015-05-01 Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms Dao, Ro-Lan Su, Shih-Chi Chung, Wen-Hung Asia Pac Allergy Current Review Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the incidence rate is low, SCAR sometimes can be life-threatening and leads to lifelong sequelae. Many pharmacogenomic associations in immune and nonimmune related genes with the development of SCAR have been discovered recently and the pharmacogenetic tests have been applied to prevent specific drug-induced SCAR. In this review, we discuss the recent advances of pharmacogenomics in SCAR. Asia Pacific Association of Allergy, Asthma and Clinical Immunology 2015-04 2015-04-29 /pmc/articles/PMC4415181/ /pubmed/25938070 http://dx.doi.org/10.5415/apallergy.2015.5.2.59 Text en Copyright © 2015. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Current Review
Dao, Ro-Lan
Su, Shih-Chi
Chung, Wen-Hung
Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
title Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
title_full Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
title_fullStr Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
title_full_unstemmed Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
title_short Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
title_sort recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
topic Current Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415181/
https://www.ncbi.nlm.nih.gov/pubmed/25938070
http://dx.doi.org/10.5415/apallergy.2015.5.2.59
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