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Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature
ᅟ: Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415214/ https://www.ncbi.nlm.nih.gov/pubmed/25902709 http://dx.doi.org/10.1186/s12969-015-0008-x |
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author | Gurion, Reut Tangpricha, Vin Yow, Eric Schanberg, Laura E McComsey, Grace A Robinson, Angela Byun |
author_facet | Gurion, Reut Tangpricha, Vin Yow, Eric Schanberg, Laura E McComsey, Grace A Robinson, Angela Byun |
author_sort | Gurion, Reut |
collection | PubMed |
description | ᅟ: Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00065806. |
format | Online Article Text |
id | pubmed-4415214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44152142015-05-01 Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature Gurion, Reut Tangpricha, Vin Yow, Eric Schanberg, Laura E McComsey, Grace A Robinson, Angela Byun Pediatr Rheumatol Online J Review ᅟ: Avascular necrosis (AVN) occurs in several chronic illnesses, including systemic lupus erythematosus (SLE), but can also occur in healthy children. There are multiple theories to explain why and how AVN occurs, but an exact mechanism has yet to be unraveled. AVN in the pediatric lupus population is understudied. The Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, provides an excellent venue to conduct an exploratory analysis to assess associations between AVN and demographics, SLE disease activity and vitamin D deficiency. Herein we present a brief report describing our findings, as well as reviewing the literature on AVN in SLE and other entities. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00065806. BioMed Central 2015-04-23 /pmc/articles/PMC4415214/ /pubmed/25902709 http://dx.doi.org/10.1186/s12969-015-0008-x Text en © Gurion et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Gurion, Reut Tangpricha, Vin Yow, Eric Schanberg, Laura E McComsey, Grace A Robinson, Angela Byun Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature |
title | Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature |
title_full | Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature |
title_fullStr | Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature |
title_full_unstemmed | Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature |
title_short | Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature |
title_sort | avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415214/ https://www.ncbi.nlm.nih.gov/pubmed/25902709 http://dx.doi.org/10.1186/s12969-015-0008-x |
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