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A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China

BACKGROUND: Imipenem-resistant Acinetobacter baumannii (IRAB) is an important cause of hospital-acquired infection. We aimed to describe an outbreak of IRAB infection and to investigate its possible source in an intensive care unit. METHODS: An environmental investigation was undertaken. Antimicrobi...

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Autores principales: Ye, Dan, Shan, Jinglan, Huang, Yongbo, Li, Jianchun, Li, Changan, Liu, Xiaoqing, He, Weiqun, Li, Yimin, Mao, Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415246/
https://www.ncbi.nlm.nih.gov/pubmed/25886493
http://dx.doi.org/10.1186/s12879-015-0917-9
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author Ye, Dan
Shan, Jinglan
Huang, Yongbo
Li, Jianchun
Li, Changan
Liu, Xiaoqing
He, Weiqun
Li, Yimin
Mao, Pu
author_facet Ye, Dan
Shan, Jinglan
Huang, Yongbo
Li, Jianchun
Li, Changan
Liu, Xiaoqing
He, Weiqun
Li, Yimin
Mao, Pu
author_sort Ye, Dan
collection PubMed
description BACKGROUND: Imipenem-resistant Acinetobacter baumannii (IRAB) is an important cause of hospital-acquired infection. We aimed to describe an outbreak of IRAB infection and to investigate its possible source in an intensive care unit. METHODS: An environmental investigation was undertaken. Antimicrobial susceptibility testing was performed by microdilution. These isolates were genotyped by use of repetitive extragenic palindromic polymerase chain reaction (rep-PCR; DiversiLab). The study included 11 patients infected with IRAB and 14 control patients free of IRAB. Case and control patients were compared for possible predisposing factors. A multifaceted intervention was implemented to control the outbreak. RESULTS: Thirty-nine IRABs were isolated from patients and the environmental surveillance culture in August, November, and December 2011. All isolates were resistant to imipenem. The IRAB strains belonged to seven clones (A–G) by the use of rep-PCR. There were four epidemic clones (D–G) in the outbreak, and Clone D was predominant. For the case–control study, patients with chronic obstructive pulmonary disease were susceptible to infection with IRAB. The hospital mortality of the case group was significantly higher than that of the control group. CONCLUSIONS: The outbreak strains were transmitted among infected patients and equipment by inappropriate use of gloves. A combination of aggressive infection control measures is essential for preventing recurrent nosocomial outbreaks of IRAB.
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spelling pubmed-44152462015-05-01 A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China Ye, Dan Shan, Jinglan Huang, Yongbo Li, Jianchun Li, Changan Liu, Xiaoqing He, Weiqun Li, Yimin Mao, Pu BMC Infect Dis Research Article BACKGROUND: Imipenem-resistant Acinetobacter baumannii (IRAB) is an important cause of hospital-acquired infection. We aimed to describe an outbreak of IRAB infection and to investigate its possible source in an intensive care unit. METHODS: An environmental investigation was undertaken. Antimicrobial susceptibility testing was performed by microdilution. These isolates were genotyped by use of repetitive extragenic palindromic polymerase chain reaction (rep-PCR; DiversiLab). The study included 11 patients infected with IRAB and 14 control patients free of IRAB. Case and control patients were compared for possible predisposing factors. A multifaceted intervention was implemented to control the outbreak. RESULTS: Thirty-nine IRABs were isolated from patients and the environmental surveillance culture in August, November, and December 2011. All isolates were resistant to imipenem. The IRAB strains belonged to seven clones (A–G) by the use of rep-PCR. There were four epidemic clones (D–G) in the outbreak, and Clone D was predominant. For the case–control study, patients with chronic obstructive pulmonary disease were susceptible to infection with IRAB. The hospital mortality of the case group was significantly higher than that of the control group. CONCLUSIONS: The outbreak strains were transmitted among infected patients and equipment by inappropriate use of gloves. A combination of aggressive infection control measures is essential for preventing recurrent nosocomial outbreaks of IRAB. BioMed Central 2015-04-11 /pmc/articles/PMC4415246/ /pubmed/25886493 http://dx.doi.org/10.1186/s12879-015-0917-9 Text en © Dan et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ye, Dan
Shan, Jinglan
Huang, Yongbo
Li, Jianchun
Li, Changan
Liu, Xiaoqing
He, Weiqun
Li, Yimin
Mao, Pu
A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China
title A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China
title_full A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China
title_fullStr A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China
title_full_unstemmed A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China
title_short A gloves-associated outbreak of imipenem-resistant Acinetobacter baumannii in an intensive care unit in Guangdong, China
title_sort gloves-associated outbreak of imipenem-resistant acinetobacter baumannii in an intensive care unit in guangdong, china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415246/
https://www.ncbi.nlm.nih.gov/pubmed/25886493
http://dx.doi.org/10.1186/s12879-015-0917-9
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