Cargando…

Detecting cathepsin activity in human osteoarthritis via activity-based probes

INTRODUCTION: Lysosomal cathepsins have been reported to contribute to Osteoarthritis (OA) pathophysiology due to their increase in pro-inflammatory conditions. Given the causal role of cathepsins in OA, monitoring their specific activity could provide means for assessing OA severity. To this end, w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ben-Aderet, Louisa, Merquiol, Emmanuelle, Fahham, Duha, Kumar, Ashok, Reich, Eli, Ben-Nun, Yael, Kandel, Leonid, Haze, Amir, Liebergall, Meir, Kosińska, Marta K, Steinmeyer, Juergen, Turk, Boris, Blum, Galia, Dvir-Ginzberg, Mona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415352/ https://www.ncbi.nlm.nih.gov/pubmed/25889265 http://dx.doi.org/10.1186/s13075-015-0586-5

Ejemplares similares

Photodynamic Quenched Cathepsin Activity Based Probes for Cancer Detection and Macrophage Targeted Therapy
por: Ben-Nun, Yael, et al.
Publicado: (2015)

A Theranostic Cathepsin Activity-Based Probe for Noninvasive Intervention in Cardiovascular Diseases
por: Weiss-Sadan, Tommy, et al.
Publicado: (2019)

Serum NT/CT SIRT1 ratio reflects early osteoarthritis and chondrosenescence
por: Batshon, George, et al.
Publicado: (2020)

Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes
por: Bar Oz, Michal, et al.
Publicado: (2016)

Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion
por: Abd-Elrahman, Ihab, et al.
Publicado: (2016)

Molecular Imaging of Cancer Using X-ray Computed Tomography with Protease Targeted Iodinated Activity-Based Probes
por: Gaikwad, Hanmant K., et al.
Publicado: (2018)

CT Imaging of Enzymatic Activity in Cancer Using Covalent Probes Reveal a Size-Dependent Pattern
por: Tsvirkun, Darya, et al.
Publicado: (2018)

Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation
por: Weiss-Sadan, Tommy, et al.
Publicado: (2019)

Improved Cathepsin Probes for Sensitive Molecular Imaging
por: Yitzhak, Yonit, et al.
Publicado: (2022)

Chopping off the chondrocyte proteome
por: Dvir-Ginzberg, Mona, et al.
Publicado: (2015)

Cysteine Cathepsin Activity Regulation by Glycosaminoglycans
por: Novinec, Marko, et al.
Publicado: (2014)

A Fenchone Derivative Effectively Abrogates Joint Damage Following Post-Traumatic Osteoarthritis in Lewis Rats
por: Carmon, Idan, et al.
Publicado: (2022)

Image-guided surgery using near-infrared Turn-ON fluorescent nanoprobes for precise detection of tumor margins
por: Blau, Rachel, et al.
Publicado: (2018)

Cathepsin B trafficking in thyroid carcinoma cells
por: Tedelind, Sofia, et al.
Publicado: (2011)

A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
por: Shaulov-Rotem, Yulia, et al.
Publicado: (2016)

Bipolar hip hemiarthroplasty in a patient with an above knee amputation: a case report
por: Kandel, Leonid, et al.
Publicado: (2009)

Repairing a critical cranial defect using WISP1-pretreated chondrocyte scaffolds
por: Carmon, Idan, et al.
Publicado: (2023)

Chondrocytes supplemented to bone graft-containing scaffolds expedite cranial defect repair
por: Carmon, Idan, et al.
Publicado: (2023)

Lef1 ablation alleviates cartilage mineralization following posttraumatic osteoarthritis induction
por: Elayyan, Jinan, et al.
Publicado: (2022)

The Induction of APC with a Distinct Tolerogenic Phenotype via Contact-Dependent STAT3 Activation
por: Gur-Wahnon, Devorah, et al.
Publicado: (2009)

Non-Invasive Imaging of Cysteine Cathepsin Activity in Solid Tumors Using a (64)Cu-Labeled Activity-Based Probe
por: Ren, Gang, et al.
Publicado: (2011)

Cathepsin Inhibition Modulates Metabolism and Polarization of Tumor-Associated Macrophages
por: Oelschlaegel, Diana, et al.
Publicado: (2020)

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes
por: Poreba, Marcin, et al.
Publicado: (2018)

SIRT1 Deficiency, Specifically in Fibroblasts, Decreases Apoptosis Resistance and Is Associated with Resolution of Lung-Fibrosis
por: Bulvik, Raanan, et al.
Publicado: (2020)

HU308 Mitigates Osteoarthritis by Stimulating Sox9‐Related Networks of Carbohydrate Metabolism
por: Carmon, Idan, et al.
Publicado: (2022)

Macrophage-Induced Lymphangiogenesis and Metastasis following Paclitaxel Chemotherapy Is Regulated by VEGFR3
por: Alishekevitz, Dror, et al.
Publicado: (2016)

Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C
por: Poreba, Marcin, et al.
Publicado: (2014)

Nitroxoline impairs tumor progression in vitro and in vivo by regulating cathepsin B activity
por: Mirković, Bojana, et al.
Publicado: (2015)

Cysteine cathepsins: From structure, function and regulation to new frontiers()
por: Turk, Vito, et al.
Publicado: (2012)

Adult female patient with osteitis pubis and pelvic instability requiring surgery: A case report
por: Nasrallah, Khalil, et al.
Publicado: (2020)

Cysteine Cathepsins and Their Extracellular Roles: Shaping the Microenvironment
por: Vidak, Eva, et al.
Publicado: (2019)

SIRT1 activity orchestrates ECM expression during hESC‐chondrogenic differentiation
por: Smith, Christopher A., et al.
Publicado: (2022)

Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target
por: Reinheckel, Thomas, et al.
Publicado: (2012)

Cathepsin B cleavage of the trypsinogen activation peptide
por: Teich, Niels, et al.
Publicado: (2002)

Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants
por: Lalmanach, Gilles, et al.
Publicado: (2020)

A comparative study on the lipidome of normal knee synovial fluid from humans and horses
por: Kosinska, Marta K., et al.
Publicado: (2021)

Amphiphilic nanocarrier-induced modulation of PLK1 and miR-34a leads to improved therapeutic response in pancreatic cancer
por: Gibori, Hadas, et al.
Publicado: (2018)

Skeletal ligament healing using the recombinant human amelogenin protein
por: Hanhan, Salem, et al.
Publicado: (2016)

Sphingolipids in Human Synovial Fluid - A Lipidomic Study
por: Kosinska, Marta Krystyna, et al.
Publicado: (2014)

Serum and Synovial Levels of Cathepsin G and Cathepsin K in Patients with Psoriatic Arthritis and Their Correlation with Disease Activity Indices
por: Popova-Belova, Stanislava Dimitrova, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u06213fdqqrguk6pjm7s13nijl