The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation

We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcεRI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcεRI. We previously reported the role of histone deacetylases (HDAC...

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Autores principales: Kim, Youngmi, Eom, Sangkyung, Park, Deokbum, Kim, Hyuna, Jeoung, Dooil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415435/
https://www.ncbi.nlm.nih.gov/pubmed/25983734
http://dx.doi.org/10.3389/fimmu.2015.00210
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author Kim, Youngmi
Eom, Sangkyung
Park, Deokbum
Kim, Hyuna
Jeoung, Dooil
author_facet Kim, Youngmi
Eom, Sangkyung
Park, Deokbum
Kim, Hyuna
Jeoung, Dooil
author_sort Kim, Youngmi
collection PubMed
description We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcεRI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcεRI. We previously reported the role of histone deacetylases (HDACs) in allergic inflammation and allergic inflammation-promoted enhanced tumorigenic potential. We reported regulatory role of HA in the expression of HDAC3. In this review, we will discuss molecular mechanisms associated with anti-allergic effect of HA in relation with HDACs. The role of microRNAs (miRNAs) in allergic inflammation has been reported. We will also discuss the role of miRNAs in allergic inflammation in relation with HA-mediated anti-allergic effects.
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spelling pubmed-44154352015-05-15 The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation Kim, Youngmi Eom, Sangkyung Park, Deokbum Kim, Hyuna Jeoung, Dooil Front Immunol Immunology We previously reported the anti-allergic effect of high molecular weight form of hyaluronic acid (HMW-HA). In doing so, HA targets CD44 and inhibits FcεRI signaling and cross-talk between epidermal growth factor receptor (EGFR) and FcεRI. We previously reported the role of histone deacetylases (HDACs) in allergic inflammation and allergic inflammation-promoted enhanced tumorigenic potential. We reported regulatory role of HA in the expression of HDAC3. In this review, we will discuss molecular mechanisms associated with anti-allergic effect of HA in relation with HDACs. The role of microRNAs (miRNAs) in allergic inflammation has been reported. We will also discuss the role of miRNAs in allergic inflammation in relation with HA-mediated anti-allergic effects. Frontiers Media S.A. 2015-04-30 /pmc/articles/PMC4415435/ /pubmed/25983734 http://dx.doi.org/10.3389/fimmu.2015.00210 Text en Copyright © 2015 Kim, Eom, Park, Kim and Jeoung. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kim, Youngmi
Eom, Sangkyung
Park, Deokbum
Kim, Hyuna
Jeoung, Dooil
The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation
title The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation
title_full The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation
title_fullStr The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation
title_full_unstemmed The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation
title_short The Hyaluronic Acid–HDAC3–miRNA Network in Allergic Inflammation
title_sort hyaluronic acid–hdac3–mirna network in allergic inflammation
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415435/
https://www.ncbi.nlm.nih.gov/pubmed/25983734
http://dx.doi.org/10.3389/fimmu.2015.00210
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