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Antifibrotic Activity of Acylated and Unacylated Ghrelin

Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fi...

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Autores principales: Angelino, Elia, Reano, Simone, Ferrara, Michele, Agosti, Emanuela, Graziani, Andrea, Filigheddu, Nicoletta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415458/
https://www.ncbi.nlm.nih.gov/pubmed/25960743
http://dx.doi.org/10.1155/2015/385682
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author Angelino, Elia
Reano, Simone
Ferrara, Michele
Agosti, Emanuela
Graziani, Andrea
Filigheddu, Nicoletta
author_facet Angelino, Elia
Reano, Simone
Ferrara, Michele
Agosti, Emanuela
Graziani, Andrea
Filigheddu, Nicoletta
author_sort Angelino, Elia
collection PubMed
description Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. Acylated and unacylated ghrelin are the main products of the ghrelin gene. The acylated form, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release. Although unacylated ghrelin does not bind or activate GHSR-1a, it shares with the acylated form several biological activities. Ghrelin peptides exhibit anti-inflammatory, antioxidative, and antiapoptotic activities, suggesting that they might represent an efficient approach to prevent or reduce fibrosis. The aim of this review is to summarize the available evidence regarding the effects of acylated and unacylated ghrelin on different pathologies and experimental models in which fibrosis is a predominant characteristic.
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spelling pubmed-44154582015-05-10 Antifibrotic Activity of Acylated and Unacylated Ghrelin Angelino, Elia Reano, Simone Ferrara, Michele Agosti, Emanuela Graziani, Andrea Filigheddu, Nicoletta Int J Endocrinol Review Article Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. Acylated and unacylated ghrelin are the main products of the ghrelin gene. The acylated form, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release. Although unacylated ghrelin does not bind or activate GHSR-1a, it shares with the acylated form several biological activities. Ghrelin peptides exhibit anti-inflammatory, antioxidative, and antiapoptotic activities, suggesting that they might represent an efficient approach to prevent or reduce fibrosis. The aim of this review is to summarize the available evidence regarding the effects of acylated and unacylated ghrelin on different pathologies and experimental models in which fibrosis is a predominant characteristic. Hindawi Publishing Corporation 2015 2015-04-16 /pmc/articles/PMC4415458/ /pubmed/25960743 http://dx.doi.org/10.1155/2015/385682 Text en Copyright © 2015 Elia Angelino et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Angelino, Elia
Reano, Simone
Ferrara, Michele
Agosti, Emanuela
Graziani, Andrea
Filigheddu, Nicoletta
Antifibrotic Activity of Acylated and Unacylated Ghrelin
title Antifibrotic Activity of Acylated and Unacylated Ghrelin
title_full Antifibrotic Activity of Acylated and Unacylated Ghrelin
title_fullStr Antifibrotic Activity of Acylated and Unacylated Ghrelin
title_full_unstemmed Antifibrotic Activity of Acylated and Unacylated Ghrelin
title_short Antifibrotic Activity of Acylated and Unacylated Ghrelin
title_sort antifibrotic activity of acylated and unacylated ghrelin
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415458/
https://www.ncbi.nlm.nih.gov/pubmed/25960743
http://dx.doi.org/10.1155/2015/385682
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