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Antifibrotic Activity of Acylated and Unacylated Ghrelin
Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415458/ https://www.ncbi.nlm.nih.gov/pubmed/25960743 http://dx.doi.org/10.1155/2015/385682 |
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author | Angelino, Elia Reano, Simone Ferrara, Michele Agosti, Emanuela Graziani, Andrea Filigheddu, Nicoletta |
author_facet | Angelino, Elia Reano, Simone Ferrara, Michele Agosti, Emanuela Graziani, Andrea Filigheddu, Nicoletta |
author_sort | Angelino, Elia |
collection | PubMed |
description | Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. Acylated and unacylated ghrelin are the main products of the ghrelin gene. The acylated form, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release. Although unacylated ghrelin does not bind or activate GHSR-1a, it shares with the acylated form several biological activities. Ghrelin peptides exhibit anti-inflammatory, antioxidative, and antiapoptotic activities, suggesting that they might represent an efficient approach to prevent or reduce fibrosis. The aim of this review is to summarize the available evidence regarding the effects of acylated and unacylated ghrelin on different pathologies and experimental models in which fibrosis is a predominant characteristic. |
format | Online Article Text |
id | pubmed-4415458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44154582015-05-10 Antifibrotic Activity of Acylated and Unacylated Ghrelin Angelino, Elia Reano, Simone Ferrara, Michele Agosti, Emanuela Graziani, Andrea Filigheddu, Nicoletta Int J Endocrinol Review Article Fibrosis can affect almost all tissues and organs, it often represents the terminal stage of chronic diseases, and it is regarded as a major health issue for which efficient therapies are needed. Tissue injury, by inducing necrosis/apoptosis, triggers inflammatory response that, in turn, promotes fibroblast activation and pathological deposition of extracellular matrix. Acylated and unacylated ghrelin are the main products of the ghrelin gene. The acylated form, through its receptor GHSR-1a, stimulates appetite and growth hormone (GH) release. Although unacylated ghrelin does not bind or activate GHSR-1a, it shares with the acylated form several biological activities. Ghrelin peptides exhibit anti-inflammatory, antioxidative, and antiapoptotic activities, suggesting that they might represent an efficient approach to prevent or reduce fibrosis. The aim of this review is to summarize the available evidence regarding the effects of acylated and unacylated ghrelin on different pathologies and experimental models in which fibrosis is a predominant characteristic. Hindawi Publishing Corporation 2015 2015-04-16 /pmc/articles/PMC4415458/ /pubmed/25960743 http://dx.doi.org/10.1155/2015/385682 Text en Copyright © 2015 Elia Angelino et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Angelino, Elia Reano, Simone Ferrara, Michele Agosti, Emanuela Graziani, Andrea Filigheddu, Nicoletta Antifibrotic Activity of Acylated and Unacylated Ghrelin |
title | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
title_full | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
title_fullStr | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
title_full_unstemmed | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
title_short | Antifibrotic Activity of Acylated and Unacylated Ghrelin |
title_sort | antifibrotic activity of acylated and unacylated ghrelin |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415458/ https://www.ncbi.nlm.nih.gov/pubmed/25960743 http://dx.doi.org/10.1155/2015/385682 |
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