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Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated chang...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Genética
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415566/ https://www.ncbi.nlm.nih.gov/pubmed/25983633 http://dx.doi.org/10.1590/S1415-475738120140137 |
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author | Yeo, Sujung An, Keon Sang Hong, Yeon-Mi Choi, Yeong-Gon Rosen, Bruce Kim, Sung-Hoon Lim, Sabina |
author_facet | Yeo, Sujung An, Keon Sang Hong, Yeon-Mi Choi, Yeong-Gon Rosen, Bruce Kim, Sung-Hoon Lim, Sabina |
author_sort | Yeo, Sujung |
collection | PubMed |
description | Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication. |
format | Online Article Text |
id | pubmed-4415566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-44155662015-05-15 Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis Yeo, Sujung An, Keon Sang Hong, Yeon-Mi Choi, Yeong-Gon Rosen, Bruce Kim, Sung-Hoon Lim, Sabina Genet Mol Biol Genomics and Bioinformatics Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication. Sociedade Brasileira de Genética 2015-03 2014-03-17 /pmc/articles/PMC4415566/ /pubmed/25983633 http://dx.doi.org/10.1590/S1415-475738120140137 Text en Copyright © 2015, Sociedade Brasileira de Genética. http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Genomics and Bioinformatics Yeo, Sujung An, Keon Sang Hong, Yeon-Mi Choi, Yeong-Gon Rosen, Bruce Kim, Sung-Hoon Lim, Sabina Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
title | Neuroprotective changes in degeneration-related gene expression in the
substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism:
Microarray analysis |
title_full | Neuroprotective changes in degeneration-related gene expression in the
substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism:
Microarray analysis |
title_fullStr | Neuroprotective changes in degeneration-related gene expression in the
substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism:
Microarray analysis |
title_full_unstemmed | Neuroprotective changes in degeneration-related gene expression in the
substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism:
Microarray analysis |
title_short | Neuroprotective changes in degeneration-related gene expression in the
substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism:
Microarray analysis |
title_sort | neuroprotective changes in degeneration-related gene expression in the
substantia nigra following acupuncture in an mptp mouse model of parkinsonism:
microarray analysis |
topic | Genomics and Bioinformatics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415566/ https://www.ncbi.nlm.nih.gov/pubmed/25983633 http://dx.doi.org/10.1590/S1415-475738120140137 |
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